TCL1A Polyklonaler Antikörper

TCL1A Polyklonal Antikörper für WB, IHC, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IHC, ELISA

Konjugation

Unkonjugiert

Publikationen

1

Kat-Nr. : 10475-1-AP

Synonyme

Oncogene TCL 1, Oncogene TCL1, Protein p14 TCL1, T cell leukemia/lymphoma 1A, TCL1, TCL1A

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Galerie der Validierungsdaten

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  WB analysis of Raji using 10475-1-AP

  Raji cells were subjected to SDS PAGE followed by western blot with 10475-1-AP (TCL1A antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

• 

  WB analysis of Raji using 10475-1-AP

  Raji cells were subjected to SDS PAGE followed by western blot with 10475-1-AP (TCL1A antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

• 

  WB analysis of Raji using 10475-1-AP

  Raji cells were subjected to SDS PAGE followed by western blot with 10475-1-AP (TCL1A antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

• 

  IHC staining of human tonsillitis using 10475-1-AP

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 10475-1-AP (TCL1A Antibody) at dilution of 1:50 (under 10x lens).

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  IHC staining of human tonsillitis using 10475-1-AP

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 10475-1-AP (TCL1A Antibody) at dilution of 1:50 (under 40x lens).

• 

  IHC staining of human lung cancer using 10475-1-AP

  Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 10475-1-AP (TCL1A Antibody) at dilution of 1:50 (under 10x lens).

• 

  IHC staining of human lung cancer using 10475-1-AP

  Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 10475-1-AP (TCL1A Antibody) at dilution of 1:50 (under 40x lens).

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: Raji-Zellen
• Erfolgreiche Detektion in IHC: humanes Tonsillitisgewebe, humanes Lungenkarzinomgewebe; Hinweis: Antigendemaskierung mit TE-Puffer pH 9,0 empfohlen. (*) Wahlweise kann die Antigendemaskierung auch mit Citratpuffer pH 6,0 erfolgen.

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:200-1:1000
• Immunhistochemie (IHC): IHC : 1:20-1:200

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• WB: See 1 publications below

Produktinformation

10475-1-AP bindet in WB, IHC, ELISA TCL1A und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• In Publikationen genannte Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: TCL1A fusion protein Ag0786
• Vollständiger Name: T-cell leukemia/lymphoma 1A
• Berechnetes Molekulargewicht: 13 kDa
• Beobachtetes Molekulargewicht: 14-16 kDa
• GenBank-Zugangsnummer: BC005831
• Gene symbol: TCL1A
• Gene ID (NCBI): 8115
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TCL1A, also named as TCL1 and p14 TCL1, enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. TCL1A immunodetection is an independent marker of adverse outcome that could be used in routine settings for the management of DLCL patients. TCL1A expression is correlated with shorter time to treatment in chronic lymphocytic leukemia cases and shorter lymphoma-specific survival in mantle cell lymphoma series. It is a potential therapeutic target.

Publikationen

Species	Application	Title
human	WB	Cell Biol Int; Protection of seven dibenzocyclooctadiene lignans from Schisandra chinensis against serum and glucose deprivation injury in SH-SY5Y cells.; Authors - Qun E