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  • KD/KO Validated

SUV39H1 Polyklonaler Antikörper

SUV39H1 Polyklonal Antikörper für WB, IP, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, IP, ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 10574-1-AP

Synonyme

H3 K9 HMTase 1, KMT1A, Lysine N methyltransferase 1A, MG44, Su(var)3 9 homolog 1, SUV39H, SUV39H1



Geprüfte Anwendungen

Erfolgreiche Detektion in WBHCT 116-Zellen, C6-Zellen, HEK-293-Zellen, HeLa-Zellen, HepG2-Zellen, Maus-Dünndarmgewebe, NIH/3T3-Zellen
Erfolgreiche IPHeLa-Zellen

Empfohlene Verdünnung

AnwendungVerdünnung
Western Blot (WB)WB : 1:2000-1:12000
Immunpräzipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

10574-1-AP bindet in WB, IHC, IP, ELISA SUV39H1 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
In Publikationen genannte Reaktivitäthuman, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen SUV39H1 fusion protein Ag0854
Vollständiger Name suppressor of variegation 3-9 homolog 1 (Drosophila)
Berechnetes Molekulargewicht 48 kDa
Beobachtetes Molekulargewicht 48-50 kDa
GenBank-ZugangsnummerBC006238
Gene symbol SUV39H1
Gene ID (NCBI) 6839
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Histone-lysine N-methyltransferase (SUV39H1), a nuclear protein, moves to the centromeres during mitosis and specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. It plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression. SUV39H1 has 2 isoforms with molecular weights of 48 and 49 kDa.

Protokolle

Produktspezifische Protokolle
WB protocol for SUV39H1 antibody 10574-1-APProtokoll herunterladen
IP protocol for SUV39H1 antibody 10574-1-APProtokoll herunterladen
Standard-Protokolle
Klicken Sie hier, um unsere Standardprotokolle anzuzeigen

Publikationen

SpeciesApplicationTitle

Nucleic Acids Res

ATM, KAP1 and the Epstein-Barr virus polymerase processivity factor direct traffic at the intersection of transcription and replication

Authors - Huanzhou Xu
mouseWB

Nat Commun

The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction.

Authors - Guang Yang
  • KO Validated
humanWB

J Med Chem

Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP-Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis.

Authors - Ting Peng
humanWB

Cell Death Dis

Dicer promotes tumorigenesis by translocating to nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells.

Authors - Wenlong Cheng
humanWB

Oncotarget

Downregulation of HP1α suppresses proliferation of cholangiocarcinoma by restoring SFRP1 expression.

Authors - Wenlong Cheng
humanWB

iScience

Linkage of methionine addiction, histone lysine hypermethylation, and malignancy.

Authors - Jun Yamamoto

Rezensionen

The reviews below have been submitted by verified Proteintech customers who received an incentive for providing their feedback.


FH

Roy (Verified Customer) (06-15-2024)

Great antibody for detecting SUV39H1 from HeLa extracts (1/1000 dilution, overnight incubation at 4°C)

  • Applications: Western Blot
  • Primary Antibody Dilution: 1/1000
  • Cell Tissue Type: HeLa