SLAMF7 Polyklonaler Antikörper

SLAMF7 Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Hausschwein, human

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

Publikationen

1

Kat-Nr. : 12905-1-AP

Synonyme

19A, CD2 subset 1, CD319, CRACC, CS1, Membrane protein FOAP 12, Novel Ly9, Protein 19A, SLAM family member 7, SLAMF7

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Galerie der Validierungsdaten

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  WB analysis using 12905-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 12905-1-AP (SLAMF7 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

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  WB analysis of pig spleen using 12905-1-AP

  pig spleen tissue were subjected to SDS PAGE followed by western blot with 12905-1-AP (SLAMF7 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

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  WB analysis of human spleen using 12905-1-AP

  human spleen tissue were subjected to SDS PAGE followed by western blot with 12905-1-AP (SLAMF7 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: IM-9 cells, Hausschwein-Milzgewebe, humanes Milzgewebe, Jurkat-Zellen

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:1000-1:4000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• WB: See 1 publications below

Produktinformation

12905-1-AP bindet in WB, ELISA SLAMF7 und zeigt Reaktivität mit Hausschwein, human

• Getestete Reaktivität: Hausschwein, human
• In Publikationen genannte Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: SLAMF7 fusion protein Ag3804
• Vollständiger Name: SLAM family member 7
• Berechnetes Molekulargewicht: 335 aa, 37 kDa
• Beobachtetes Molekulargewicht: 66 kDa
• GenBank-Zugangsnummer: BC027867
• Gene symbol: SLAMF7
• Gene ID (NCBI): 57823
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Signaling lymphocyte activation molecule (SLAM) family receptors is a group of type I transmembrane receptors belonging to the immunoglobulin superfamily (PMID: 37251372). The SLAM family contains nine members that contain an extracellular segment comprising two or four Ig-like domains (V-like variable and C2-like constant), a transmembrane region and a cytoplasmic tail (PMID: 29662641). They are involved in various physiological and pathological processes, including the regulation of immunological responses and the route of viral entry. SLAMF7, also known as CS1, CRACC or CD319, is expressed on NK cells, CD8+ T lymphocytes, B lymphocytes, and mature dendritic cells (PMID: 28861320). It exerts both activating and inhibitory effects depending on the expression status of SAP or EAT-2. SLAMF7 is overexpressed in multiple myeloma and makes it a target for immunotherapy (PMID: 28861320). The native molecular weight of SLAMF7 is 37 kDa and the apparent molecular mass shifts due to glycosylation (PMID: 11698418; 36381324).

Publikationen

Species	Application	Title
human	WB	Int J Chron Obstruct Pulmon Dis; Analysis of Key Genes and miRNA-mRNA Networks Associated with Glucocorticoids Treatment in Chronic Obstructive Pulmonary Disease; Authors - Jian-Jun Wu