SCARF1 Polyklonaler Antikörper

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• KD/KO Validated

SCARF1 Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus und mehr (1)

Anwendung

WB, IF, FC, ELISA

Konjugation

Unkonjugiert

Publikationen

4

Kat-Nr. : 13702-1-AP

Synonyme

Acetyl LDL receptor, KIAA0149, SCARF1, SREC, SREC-I

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Galerie der Validierungsdaten

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  WB analysis using 13702-1-AP

  Boiled mouse lung tissue and unboiled mouse lung tissue were subjected to SDS PAGE followed by western blot with 13702-1-AP (SCARF1 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: Mauslungengewebe, unboiled mouse lung tissue

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:500-1:3000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 1 publications below
• WB: See 1 publications below
• IF: See 1 publications below
• FC: See 1 publications below

Produktinformation

13702-1-AP bindet in WB, IF, FC, ELISA SCARF1 und zeigt Reaktivität mit human, Maus

• Getestete Reaktivität: human, Maus
• In Publikationen genannte Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: SCARF1 fusion protein Ag4621
• Vollständiger Name: scavenger receptor class F, member 1
• Berechnetes Molekulargewicht: 830 aa, 87 kDa
• Beobachtetes Molekulargewicht: 87 kDa
• GenBank-Zugangsnummer: BC039735
• Gene symbol: SCARF1
• Gene ID (NCBI): 8578
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Scavenger receptor class F member 1 (SCARF1), also known as scavenger receptor expressed by endothelial cells (SREC)-I, belongs to the scavenger receptor (SR) superfamily. SCARF1 has been shown to bind modified low density lipoproteins (LDLs), including acetylated (Ac-) and oxidized (ox-) LDLs (PMID: 29725698; PMID: 15145948). In addition to binding and internalizing a diverse range of endogenous proteins, SCARF1 also binds a wide array of viral, fungal, and bacterial antigens (PMID: 29242513). SCARF1 has a calculated molecular weight of 87 kDa, with a molecular weight of 140-160 kDa due to N-glycosylation (PMID: 22279061; PMID: 15145948). SCARF1 can also exist as a dimer (~ 180 kDa) and a truncated soluble form (~ 60 kDa) (PMID: 29242513; PMID: 29725698).

Publikationen

Species	Application	Title
mouse	IF	Nat Immunol; The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity.; Authors - Ramirez-Ortiz Zaida G ZG ; KO Validated
rat	WB	Cell Prolif; SCARF1 promotes M2 polarization of Kupffer cells via calcium-dependent PI3K-AKT-STAT3 signalling to improve liver transplantation.; Authors - Xue-Song Xu
human	FC	Front Immunol; Neutrophil heterogeneity in complement C1q expression associated with sepsis mortality; Authors - Alissa Trzeciak
mouse		Cell Rep; Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development.; Authors - Tamihiro Kamata