PTPRO Polyklonaler Antikörper

PTPRO Polyklonal Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, CoIP, ELISA

Konjugation

Unkonjugiert

Publikationen

12

Kat-Nr. : 12161-1-AP

Synonyme

GLEPP1, PTP U2, PTPase U2, PTPRO, PTPU2, R PTP O

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Galerie der Validierungsdaten

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Geprüfte Anwendungen

Veröffentlichte Anwendungen

• KD/KO: See 3 publications below
• WB: See 12 publications below
• IHC: See 3 publications below
• CoIP: See 1 publications below

Produktinformation

12161-1-AP bindet in WB, IHC, CoIP, ELISA PTPRO und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• In Publikationen genannte Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: PTPRO fusion protein Ag2802
• Vollständiger Name: protein tyrosine phosphatase, receptor type, O
• Berechnetes Molekulargewicht: 138 kDa
• GenBank-Zugangsnummer: BC035960
• Gene symbol: PTPRO
• Gene ID (NCBI): 5800
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

PTPRO(receptor-type tyrosine-protein phosphatase O) is also named as GLEPP1, PTPU2 and belongs to the protein-tyrosine phosphatase family. The protein is a receptor-like membrane protein tyrosine phosphatase expressed at the apical membrane of the podocyte foot processes in the kidney(PMID:21722858). The 1,159-amino acid predicted mature protein contains a large extracellular domain, a single transmembrane domain, and a single intracellular PTPase domain. Defects in PTPRO are the cause of nephrotic syndrome type 6 (NPHS6). In reducing conditions, PTPRO can form a smear from 180 to 220 kDa; In non-reducing conditions, a band appeares around 350 kDa, which likely represents the dimeric form of full-length PTPRO (PMID: 19573017).

Publikationen

Species	Application	Title
human, mouse	WB	Hepatology; Estrogen-sensitive PTPRO expression represses hepatocellular carcinoma progression by control of STAT3.; Authors - Hou Jiajie J
mouse	WB,IHC	J Hepatol; PTPRO plays a dual role in hepatic ischemia reperfusion injury through feedback activation of NF-κB.; Authors - Hou Jiajie J
mouse	WB	Oncotarget; PTPRO-mediated autophagy prevents hepatosteatosis and tumorigenesis.; Authors - Wenjie Zhang
human,mouse	WB	Cancer Commun (Lond); PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.; Authors - Weixing Dai
mouse	WB	Cell Physiol Biochem; PTPRO Promotes Oxidized Low-Density Lipoprotein Induced Oxidative Stress and Cell Apoptosis through Toll-Like Receptor 4/Nuclear Factor κB Pathway.; Authors - Caihong Liang
human	WB	Front Pharmacol; Tyrosine Phosphatase PTPRO Deficiency in ERBB2-Positive Breast Cancer Contributes to Poor Prognosis and Lapatinib Resistance.; Authors - Hongmei Dong ; KD Validated