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PMS1 Polyklonaler Antikörper

PMS1 Polyklonal Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 10859-1-AP

Synonyme

HNPCC3, hPMS1, PMS1, PMS1 protein homolog 1, PMSL1

Galerie der Validierungsdaten

Geprüfte Anwendungen

Veröffentlichte Anwendungen

WBSee 1 publications below
IHCSee 2 publications below

Produktinformation

10859-1-AP bindet in WB, IHC, ELISA PMS1 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
In Publikationen genannte Reaktivitäthuman
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen PMS1 fusion protein Ag1158
Vollständiger Name PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
Berechnetes Molekulargewicht 106 kDa
GenBank-ZugangsnummerBC008410
Gene symbol PMS1
Gene ID (NCBI) 5378
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The multiple eukaryotic homologs of the bacterial MutL mismatch repair protein are implicated along with MutS homologs in maintaining genomic integrity during DNA replication and recombination [PMID:16612326]. DNA mismatch repair (MMR) corrects replication errors that would otherwise lead to mutations and, potentially, various forms of cancer. Among several proteins required for eukaryotic MMR, MutLα is a heterodimer comprised of Mlh1 and PMS1 [PMID:19115045]. PMS1 contains an N-terminal domain (NTD) and C-terminal domain (CTD) ,which separated by a flexible linker. Dimerization occurs between the CTDs and the CTD of PMS1 houses a strand-specific endonuclease that is necessary for MMR [PMID:17951253].

Publikationen

SpeciesApplicationTitle
humanIHC

Breast Cancer Res

Tumor sequencing is useful to refine the analysis of germline variants in unexplained high-risk breast cancer families.

Authors - Cédric Van Marcke
View Article
humanWB, IHC

J Mol Med (Berl)

PMID: 31201471

Authors - Xiaoyu Cao
View Article