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PLAGL2 Polyklonaler Antikörper

PLAGL2 Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, IP, IF, IHC, ChIP, ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 11540-1-AP

Synonyme

KIAA0198, PLAGL2, Zinc finger protein PLAGL2



Geprüfte Anwendungen

Erfolgreiche Detektion in WBRaji-Zellen, Mausnierengewebe

Empfohlene Verdünnung

AnwendungVerdünnung
Western Blot (WB)WB : 1:1000-1:4000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

11540-1-AP bindet in WB, IP, IF, IHC, ChIP, ELISA PLAGL2 und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
In Publikationen genannte Reaktivitäthuman, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen PLAGL2 fusion protein Ag2137
Vollständiger Name pleiomorphic adenoma gene-like 2
Berechnetes Molekulargewicht 496 aa, 55 kDa
Beobachtetes Molekulargewicht 50-55 kDa, 70 kDa
GenBank-ZugangsnummerBC023655
Gene symbol PLAGL2
Gene ID (NCBI) 5326
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

PLAGL2, also named KIAA0198, belongs to the krueppel C2H2-type zinc-finger protein family. It shows weak transcriptional activatory activity. PLAGL2, a proto-oncogene, is implicated in a variety of cancers including acute myeloid leukemia (AML), malignant glioma, colon cancer, and lung adenocarcinoma. PLAGL2 can function as a tumor suppressor by initiating cell cycle arrest and apoptosis. The calculated molecular weight of PLAGL2 is 55 kDa, but the SUMO1-modifIed form is 68 kDa (PMID: 30535429).

Protokolle

Produktspezifische Protokolle
WB protocol for PLAGL2 antibody 11540-1-APProtokoll herunterladen
Standard-Protokolle
Klicken Sie hier, um unsere Standardprotokolle anzuzeigen

Publikationen

SpeciesApplicationTitle
humanWB,IHC,IF

EBioMedicine

PLAGL2 and POFUT1 are regulated by an evolutionarily conserved bidirectional promoter and are collaboratively involved in colorectal cancer by maintaining stemness.

Authors - Daojiang Li
  • KD Validated
humanIP

Cancers (Basel)

Overexpression of GATA5 Inhibits Prostate Cancer Progression by Regulating PLAGL2 via the FAK/PI3K/AKT Pathway.

Authors - Qinghua Wang
human,mouseWB,IHC,IF

Carcinogenesis

PLAGL2 promotes Snail expression and gastric cancer progression via UCA1/miR-145-5p/YTHDF1 axis

Authors - Wen Chen
humanWB

Apoptosis

Pleomorphic adenoma gene-like 2 regulates expression of the p53 family member, p73, and induces cell cycle block and apoptosis in human promonocytic U937 cells.

Authors - Hanks Tracey S TS
humanWB,IHC

Pediatr Res

Increased miR-214 expression suppresses cell migration and proliferation in Hirschsprung disease by interacting with PLAGL2.

Authors - Liang Wu
  • KD Validated
humanWB,IF

Gene

Modulation of PLAGL2 transactivation by positive cofactor 2 (PC2), a component of the ARC/Mediator complex.

Authors - Wezensky Sara J SJ