PGRMC1 Monoklonaler Antikörper

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• KD/KO Validated

PGRMC1 Monoklonal Antikörper für IF-P

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

Hausschwein, human, Maus, Ratte

Anwendung

IF-P

Konjugation

CoraLite®594 Fluorescent Dye

CloneNo.

1C10D11

Kat-Nr. : CL594-66372

Synonyme

HPR6.6, MPR, PGRMC, PGRMC1

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  IF Staining of human ovary tumor using CL594-66372

  Immunofluorescent analysis of (4% PFA) fixed human ovary tumor tissue using CoraLite®594 PGRMC1 antibody (CL594-66372, Clone: 1C10D11 ) at dilution of 1:200.

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  IF Staining of human ovary tumor using CL594-66372

  Immunofluorescent analysis of (4% PFA) fixed human ovary tumor tissue using CoraLite®594 PGRMC1 antibody (CL594-66372, Clone: 1C10D11 ) at dilution of 1:200.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in IF-P: humanes Ovarialkarzinomgewebe

Empfohlene Verdünnung

• Immunfluoreszenz (IF)-P: IF-P : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Produktinformation

CL594-66372 bindet in IF-P PGRMC1 und zeigt Reaktivität mit Hausschwein, human, Maus, Ratten

• Getestete Reaktivität: Hausschwein, human, Maus, Ratte
• Wirt / Isotyp: Maus / IgG1
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: PGRMC1 fusion protein Ag3643
• Vollständiger Name: progesterone receptor membrane component 1
• Berechnetes Molekulargewicht: 195 aa, 22 kDa
• Beobachtetes Molekulargewicht: 25-27 kDa
• GenBank-Zugangsnummer: BC034238
• Gene symbol: PGRMC1
• Gene ID (NCBI): 10857
• Konjugation: CoraLite®594 Fluorescent Dye
• Excitation/Emission maxima wavelengths: 588 nm / 604 nm
• Form: Liquid
• Reinigungsmethode: Protein-G-Reinigung
• Lagerungspuffer: PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA
• Lagerungsbedingungen: Bei -20°C lagern. Vor Licht schützen. Nach dem Versand ein Jahr stabil. Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Progesterone receptor membrane component 1 (PGRMC1) is a member of a multi-protein progesterone-binding complex. However, PGRMC1 shares homology with cytochrome b5-related proteins rather than hormone receptors (PMID: 18992768). It is a heme binding protein with biding sites for Src homology (SH2) and SH3 domain-containing proteins (PMID: 17583495). PGRMC1 is overexpressed in a variety of cancers, and thus represents an important biomarker for cancer progression and a potential target for anticancer drugs (PMID: 21730960). In nonmalignant tissues, PGRMC1 is highly expressed in the liver and kidney (PMID: 9705155; 20164297).