PCSK5 Polyklonaler Antikörper

• Featured Product
• KD/KO Validated

PCSK5 Polyklonal Antikörper für IHC, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus und mehr (1)

Anwendung

IHC, ELISA

Konjugation

Unkonjugiert

Publikationen

2

Kat-Nr. : 16470-1-AP

Synonyme

hPC6, PC5, PC6, PC6A, PCSK5, Proprotein convertase 5, Proprotein convertase 6, SPC6

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Galerie der Validierungsdaten

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  IHC staining of human kidney using 16470-1-AP

  Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 16470-1-AP (PCSK5 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human kidney using 16470-1-AP

  Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 16470-1-AP (PCSK5 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of mouse brain using 16470-1-AP

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 16470-1-AP (PCSK5 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of mouse brain using 16470-1-AP

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 16470-1-AP (PCSK5 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human skin using 16470-1-AP

  Immunohistochemical analysis of paraffin-embedded human skin using 16470-1-AP (PC6 antibody) at dilution of 1:100 (under 10x lens).

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  IHC staining of human skin using 16470-1-AP

  Immunohistochemical analysis of paraffin-embedded human skin using 16470-1-AP (PC6 antibody) at dilution of 1:100 (under 40x lens).

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  IHC staining of human spleen using 16470-1-AP

  Immunohistochemical analysis of paraffin-embedded human spleen using 16470-1-AP (PC6 antibody) at dilution of 1:200 (under 40x lens).

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  IHC staining of human heart using 16470-1-AP

  Immunohistochemical analysis of paraffin-embedded human heart using 16470-1-AP (PC6 antibody) at dilution of 1:200 (under 10x lens).

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  IHC staining of human heart using 16470-1-AP

  Immunohistochemical analysis of paraffin-embedded human heart using 16470-1-AP (PC6 antibody) at dilution of 1:200 (under 40x lens).

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  IHC staining of human testis using 16470-1-AP

  Immunohistochemical analysis of paraffin-embedded human testis using 16470-1-AP (PC6 antibody) at dilution of 1:200 (under 10x lens).

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  IHC staining of human testis using 16470-1-AP

  Immunohistochemical analysis of paraffin-embedded human testis using 16470-1-AP (PC6 antibody) at dilution of 1:200 (under 40x lens).

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  IHC staining of human spleen using 16470-1-AP

  Immunohistochemical analysis of paraffin-embedded human spleen using 16470-1-AP (PC6 antibody) at dilution of 1:200 (under 10x lens).

• 

  IHC staining of human brain using 16470-1-AP

  Immunohistochemical analysis of paraffin-embedded human brain using 16470-1-AP (PC6 antibody) at dilution of 1:50 (under 10x lens).

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  IHC staining of human brain using 16470-1-AP

  Immunohistochemical analysis of paraffin-embedded human brain using 16470-1-AP (PC6 antibody) at dilution of 1:50 (under 40x lens).

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Geprüfte Anwendungen

• Erfolgreiche Detektion in IHC: humanes Nierengewebe, humanes Hautgewebe, humanes Herzgewebe, humanes Hirngewebe, humanes Hodengewebe, humanes Milzgewebe, Maushirngewebe; Hinweis: Antigendemaskierung mit TE-Puffer pH 9,0 empfohlen. (*) Wahlweise kann die Antigendemaskierung auch mit Citratpuffer pH 6,0 erfolgen.

Empfohlene Verdünnung

• Immunhistochemie (IHC): IHC : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 1 publications below

Produktinformation

16470-1-AP bindet in IHC, ELISA PCSK5 und zeigt Reaktivität mit human, Maus

• Getestete Reaktivität: human, Maus
• In Publikationen genannte Reaktivität: human, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: PCSK5 fusion protein Ag9552
• Vollständiger Name: proprotein convertase subtilisin/kexin type 5
• Berechnetes Molekulargewicht: 102 kDa, 207 kDa
• Beobachtetes Molekulargewicht: 210 kDa
• GenBank-Zugangsnummer: BC012064
• Gene symbol: PCSK5
• Gene ID (NCBI): 5125
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

PC5 ,a mammalian kex2-like processing endoprotease, mediates posttranslational endoproteolytic processing for several integrin alpha subunits.It has been identified in rat and mouse endocrine and neuroendocrine tissues,and is encoded by multiple mRNAs that generate two splice variant isoforms referred to as PC5A (102KDa) and PC5B (207KDa) .PC5A is smaller than PC5B and it can be processed into two forms (117 kDa and 65 kDa) in neuronal cells(PMID:11457520).

Publikationen

Species	Application	Title
rat		Mol Med Rep; MicroRNA‑338‑3p regulates age‑associated osteoporosis via targeting PCSK5.; Authors - Jie Tong ; KD Validated
human		Biochem Biophys Rep; Secreted factors from adipose tissue-derived mesenchymal stem cells suppress oxygen/glucose deprivation-induced cardiomyocyte cell death via furin/PCSK-like enzyme activity.; Authors - Yuki Tachida