NeutraKine®IL-9 Monoklonaler Antikörper

NeutraKine®IL-9 Monoklonal Antikörper für Neutralization, ELISA

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human

Anwendung

Neutralization, ELISA

Konjugation

Unkonjugiert

CloneNo.

1B3A10

Kat-Nr. : 69031-1-Ig

Synonyme

Cytokine P40, HP40, IL 9, IL9, IL-9, interleukin 9, P40, T cell growth factor P40

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Galerie der Validierungsdaten

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  Neutralization experiment of NeutraKine®IL-9 using 69031-1-Ig

  Recombinant human IL-9 (Cat.NO. HZ-1240) stimulates proliferation of the MO7e human megakaryoblastic leukemia cell line in a dose-dependent manner (blue curve, refer to bottom X-left Y). The activity of human IL-9 (0.8 ng/mL HZ-1240) is neutralized by mouse anti-human IL-9 monoclonal antibody 69031-1-Ig at serial dose (red curve, refer to top X-right Y). The ND50 is typically 0.2-1.0 μg/mL. Mouse IgG1 Isotype Control monoclonal antibody 66360-1-Ig was served as control (green curve, refer to top X-right Y axis).

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Neutralization

Produktinformation

69031-1-Ig bindet in Neutralization, ELISA NeutraKine®IL-9 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Maus / IgG2a
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: human HumankineIL-9 protein HZ-1240
• Vollständiger Name: interleukin 9
• Gene symbol: IL9
• Gene ID (NCBI): 3578
• Konjugation: Unkonjugiert
• Form: Lyophilized Powder
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: Sterile PBS.
• Endotoxin: <0.1 EU/μg
• Wiederherstellung: This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.
• Stability and Storage: Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.

Hintergrundinformationen

Interleukin 9 (IL-9) is a γc-family cytokine that is highly produced by T-helper 9 (Th9) cells. IL-9 could promote the survival and activation of various cellular targets, including mast cells, B cells, T cells, and structural cells. Its expression is considered a hallmark of Th2-lineage cells. Primarily studied in Th2-type immunity, IL-9 was shown to be involved in asthma, allergy, and host defense against helminth infections. IL-9 also stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes.

This antibody can be used to neutralize the bioactivity of IL-9.