M-CSF Polyklonaler Antikörper

M-CSF Polyklonal Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human und mehr (1)

Anwendung

WB, IF, Cell treatment, ELISA

Konjugation

Unkonjugiert

Publikationen

9

Kat-Nr. : 14779-1-AP

Synonyme

CSF 1, CSF1, Lanimostim, M CSF, MCSF, M-CSF

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Galerie der Validierungsdaten

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Geprüfte Anwendungen

Empfohlene Verdünnung

Anwendung	Verdünnung
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• WB: See 8 publications below
• IF: See 1 publications below

Produktinformation

14779-1-AP bindet in WB, IF, Cell treatment, ELISA M-CSF und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• In Publikationen genannte Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: M-CSF fusion protein Ag6294
• Vollständiger Name: colony stimulating factor 1 (macrophage)
• Berechnetes Molekulargewicht: 60 kDa
• Beobachtetes Molekulargewicht: 70 kDa
• GenBank-Zugangsnummer: BC021117
• Gene symbol: CSF1
• Gene ID (NCBI): 1435
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Colony stimulating factor-1 (CSF-1) is a homodimeric glycoprotein that humorally regulates the proliferation and differentiation of mononuclear phagocytic cells and locally regulates cells of the female reproductive tract. Alternative splicing of the human CSF-1 mRNA leads to alternative expression of the CSF-1 homodimer as a secreted glycoprotein or as a membrane-spanning molecule with cell surface biological activity. CSF-1 is predominantly secreted as highly sulfated species of 375- and 250-kDa with a smaller amount of a 100-kDa species. The three predominant CSF-1 species were shown to be an 80-kDa homodimer, an 80-kDa/50-kDa heterodimer, and a 50-kDa homodimer. (PMID: 1733926) This antibody could recognieze 60 kDa, 48 kDa, 29 kDa isoforms.

Publikationen

Species	Application	Title
mouse	WB	J Control Release; Chemoattractants driven and microglia based biomimetic nanoparticle treating TMZ-resistant glioblastoma multiforme.; Authors - Sai Qiao
mouse	WB,Cell treatment	J Nanobiotechnology; Biomimetic GBM-targeted drug delivery system boosting ferroptosis for immunotherapy of orthotopic drug-resistant GBM.; Authors - Bao Liu
	WB	Biomed Pharmacother; Anti-osteoporotic effects of alisol C 23-acetate via osteoclastogenesis inhibition.; Authors - Xiaokang Jia
human	WB	Int J Biol Sci; Macrophage Colony-stimulating Factor Mediates the Recruitment of Macrophages in Triple negative Breast Cancer.; Authors - Xiaoqing Lu
human,mouse	WB	Invest Ophthalmol Vis Sci; CSF1/CSF1R-mediated Crosstalk Between Choroidal Vascular Endothelial Cells and Macrophages Promotes Choroidal Neovascularization.; Authors - Yamei Zhou
mouse	WB	Front Physiol; Heat Stress Modulates a Placental Immune Response Associated With Alterations in the Development of the Fetal Intestine and Its Innate Immune System in Late Pregnant Mouse.; Authors - Huiduo Guo