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EXT1 Polyklonaler Antikörper

EXT1 Polyklonal Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

IF, IHC, ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 10117-1-AP

Synonyme

exostoses (multiple) 1, Exostosin 1, EXT, EXT1, LGCR, LGS, Multiple exostoses protein 1, TRPS2, ttv

Galerie der Validierungsdaten

Geprüfte Anwendungen

Veröffentlichte Anwendungen

IHCSee 1 publications below
IFSee 1 publications below

Produktinformation

10117-1-AP bindet in IF, IHC, ELISA EXT1 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
In Publikationen genannte ReaktivitätMaus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen EXT1 fusion protein Ag0171
Vollständiger Name exostoses (multiple) 1
Berechnetes Molekulargewicht 86 kDa
GenBank-ZugangsnummerBC001174
Gene symbol EXT1
Gene ID (NCBI) 2131
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Hereditary multiple exostoses (EXT) is an autosomal dominant disorder characterized by the formation of cartilage-capped tumors (exostoses) that develop from the growth plate of endochondral bone. This condition can lead to skeletal abnormalities, short stature and malignant transformation of exostoses to chondrosarcomas or osteosarcomas. Linkage analyses have identified three different genes for EXT, EXT1 on 8q24.1, EXT2 on 11p11-13 and EXT3 on 19p, a family of tumor suppressor genes. Most EXT cases have been attributed to missense or frameshift mutations, which lead to loss of function of the EXT genes. EXT1 is an ER-resident type II transmembrane glycoprotein and a heparan sulphate polymerase with both D-glucuronyl and N-acetyl-D-glucosaminoglycan transferase activities. Expression of EXT1 in cells results in the alteration of the synthesis and display of cell surface heparan sulfate glycosaminoglycans. EXT1 mutations have been identified in multiple types of human tumors.

Publikationen

SpeciesApplicationTitle
mouseIHC,IF

Am J Physiol Gastrointest Liver Physiol

Altered gastric chief cell lineage differentiation in histamine-deficient mice.

Authors - Nozaki Koji K
View Article