DUSP6 Polyklonaler Antikörper
DUSP6 Polyklonal Antikörper für ELISA
Wirt / Isotyp
Kaninchen / IgG
Getestete Reaktivität
human und mehr (2)
Anwendung
WB, IHC, ELISA
Konjugation
Unkonjugiert
Kat-Nr. : 10433-1-AP
Synonyme
Galerie der Validierungsdaten
Geprüfte Anwendungen
Veröffentlichte Anwendungen
WB | See 4 publications below |
IHC | See 1 publications below |
Produktinformation
10433-1-AP bindet in WB, IHC, ELISA DUSP6 und zeigt Reaktivität mit human
Getestete Reaktivität | human |
In Publikationen genannte Reaktivität | human, Maus, Ratte |
Wirt / Isotyp | Kaninchen / IgG |
Klonalität | Polyklonal |
Typ | Antikörper |
Immunogen | DUSP6 fusion protein Ag0705 |
Vollständiger Name | dual specificity phosphatase 6 |
Berechnetes Molekulargewicht | 42 kDa |
GenBank-Zugangsnummer | BC003562 |
Gene symbol | DUSP6 |
Gene ID (NCBI) | 1848 |
Konjugation | Unkonjugiert |
Form | Liquid |
Reinigungsmethode | Antigen-Affinitätsreinigung |
Lagerungspuffer | PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3. |
Lagerungsbedingungen | Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
Dual specificity phosphatase 6 (DUSP6) is a member of the family of mitogen-activated protein kinase (MAPK) phosphatases, which dephosphorylate and inactivate MAPK (PMID: 9858808). The MAPK pathway is an important signal transduction system that serves cellular processes, such as proliferation, differentiation, migration, and apoptosis. DUSP6 resides at chromosome location 12q22-23, which is one of the candidate loci for susceptibility to bipolar disorder and which encodes a phosphatase selective for extracellular signal-regulated kinase (ERK) (PMID: 9205128). DUSP6 inactivates extracellular signal-regulated kinase (ERK), and can act in tumor suppressive pathways, whose expression is reduced in several different types of cancer. (PMID: 21680106).
Publikationen
Species | Application | Title |
---|---|---|
Br J Pharmacol L-Hcy-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinemia. | ||
Ren Fail LncTUG1 ameliorates renal tubular fibrosis in experimental diabetic nephropathy through the miR-145-5p/dual-specificity phosphatase 6 axis | ||
Mol Cell Biochem PP2A and DUSP6 are involved in sphingosylphosphorylcholine-induced hypopigmentation. | ||
Chin Med J (Engl) Higher intratumor than peritumor expression of DUSP6/MKP-3 is associated with recurrence after curative resection of hepatocellular carcinoma. | ||
Biochim Biophys Acta VRK3-mediated inactivation of ERK signaling in adult and embryonic rodent tissues. |