DUSP6 Polyklonaler Antikörper

DUSP6 Polyklonal Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human und mehr (2)

Anwendung

WB, IHC, ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 10433-1-AP

Synonyme

dual specificity phosphatase 6, DUSP6, MAP kinase phosphatase 3, MKP 3, MKP3, PYST1



Geprüfte Anwendungen

Veröffentlichte Anwendungen

WBSee 4 publications below
IHCSee 1 publications below

Produktinformation

10433-1-AP bindet in WB, IHC, ELISA DUSP6 und zeigt Reaktivität mit human

Getestete Reaktivität human
In Publikationen genannte Reaktivitäthuman, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen DUSP6 fusion protein Ag0705
Vollständiger Name dual specificity phosphatase 6
Berechnetes Molekulargewicht42 kDa
GenBank-ZugangsnummerBC003562
Gene symbol DUSP6
Gene ID (NCBI) 1848
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Dual specificity phosphatase 6 (DUSP6) is a member of the family of mitogen-activated protein kinase (MAPK) phosphatases, which dephosphorylate and inactivate MAPK (PMID: 9858808). The MAPK pathway is an important signal transduction system that serves cellular processes, such as proliferation, differentiation, migration, and apoptosis. DUSP6 resides at chromosome location 12q22-23, which is one of the candidate loci for susceptibility to bipolar disorder and which encodes a phosphatase selective for extracellular signal-regulated kinase (ERK) (PMID: 9205128). DUSP6 inactivates extracellular signal-regulated kinase (ERK), and can act in tumor suppressive pathways, whose expression is reduced in several different types of cancer. (PMID: 21680106).

Publikationen

SpeciesApplicationTitle
humanWB

Br J Pharmacol

L-Hcy-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinemia.

Authors - Yi-Ping Leng
mouseWB

Ren Fail

LncTUG1 ameliorates renal tubular fibrosis in experimental diabetic nephropathy through the miR-145-5p/dual-specificity phosphatase 6 axis

Authors - Taoxia Wang
mouseWB

Mol Cell Biochem

PP2A and DUSP6 are involved in sphingosylphosphorylcholine-induced hypopigmentation.

Authors - Jeong Hyo-Soon HS
humanIHC

Chin Med J (Engl)

Higher intratumor than peritumor expression of DUSP6/MKP-3 is associated with recurrence after curative resection of hepatocellular carcinoma.

Authors - Bo Yang
ratWB

Biochim Biophys Acta

VRK3-mediated inactivation of ERK signaling in adult and embryonic rodent tissues.

Authors - Kang Tae-Hong TH