DPEP1 Polyklonaler Antikörper

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• KD/KO Validated

DPEP1 Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte und mehr (1)

Anwendung

WB, FC, IHC, ELISA

Konjugation

Unkonjugiert

Publikationen

6

Kat-Nr. : 12222-1-AP

Synonyme

Dehydropeptidase I, Dipeptidase 1, dipeptidase 1 (renal), DPEP1, hRDP, MBD1, MDP, Microsomal dipeptidase, RDP, Renal dipeptidase

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Galerie der Validierungsdaten

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  WB analysis using 12222-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 12222-1-AP (DPEP1 antibody) at dilution of 1:2500 incubated at room temperature for 1.5 hours.

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  WB analysis of mouse liver using 12222-1-AP

  mouse liver tissue were subjected to SDS PAGE followed by western blot with 12222-1-AP (DPEP1 Antibody) at dilution of 1:300 incubated at 4 degree celsius over night.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: HepG2-Zellen, HEK-293-Zellen, Mauslebergewebe

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:1000-1:5000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 3 publications below
• WB: See 4 publications below
• IHC: See 1 publications below
• FC: See 1 publications below

Produktinformation

12222-1-AP bindet in WB, FC, IHC, ELISA DPEP1 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• In Publikationen genannte Reaktivität: human, Affe, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: DPEP1 fusion protein Ag2907
• Vollständiger Name: dipeptidase 1 (renal)
• Berechnetes Molekulargewicht: 411 aa, 46 kDa
• Beobachtetes Molekulargewicht: 46 kDa
• GenBank-Zugangsnummer: BC017023
• Gene symbol: DPEP1
• Gene ID (NCBI): 1800
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

DPEP1(Dipeptidase 1) is also named as MDP, RDP and belongs to the peptidase M19 family. It is a glycoprotein that plays an important role in the regulation of leukotriene activity. DPEP1 converts lekotriene D4 to leukotriene E4.

Publikationen

Species	Application	Title
mouse,human	WB	Cell; Dipeptidase-1 Is an Adhesion Receptor for Neutrophil Recruitment in Lungs and Liver.; Authors - Saurav Roy Choudhury ; KO Validated
human	WB,FC	Sci Adv; Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor-induced dipeptidase-1 expression and glutathione depletion.; Authors - Anne von Mässenhausen ; KD Validated
human	IHC	Sci Adv; Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury.; Authors - Arthur Lau
monkey		J Clin Invest; Renal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury.; Authors - Arthur Lau
mouse	WB	Nat Commun; A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis.; Authors - Yuting Guan ; KO Validated
mouse,human	WB	Int Immunopharmacol; Dipeptidase 1 promotes ferroptosis in renal tubular epithelial cells in diabetic nephropathy via inhibition of the GSH/GPX4 axis; Authors - Yan Li