BMP2 Polyklonaler Antikörper

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• KD/KO Validated

BMP2 Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human und mehr (3)

Anwendung

WB, IHC, IF, ELISA

Konjugation

Unkonjugiert

Publikationen

54

Kat-Nr. : 18933-1-AP

Synonyme

BMP 2, BMP 2A, BMP2, BMP-2, BMP2A, bone morphogenetic protein 2, Bone morphogenetic protein 2A

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Galerie der Validierungsdaten

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  WB analysis of HeLa using 18933-1-AP

  HeLa cells were subjected to SDS PAGE followed by western blot with 18933-1-AP (BMP2 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: HeLa-Zellen

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:500-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 2 publications below
• WB: See 47 publications below
• IHC: See 12 publications below
• IF: See 6 publications below

Produktinformation

18933-1-AP bindet in WB, IHC, IF, ELISA BMP2 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• In Publikationen genannte Reaktivität: human, hamster, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: BMP2 fusion protein Ag13501
• Vollständiger Name: bone morphogenetic protein 2
• Berechnetes Molekulargewicht: 396 aa, 44 kDa
• GenBank-Zugangsnummer: BC069214
• Gene symbol: BMP2
• Gene ID (NCBI): 650
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Bone morphogenetic protein-2 (BMP-2) is a member of the transforming growth factor-beta (TGFB) superfamily. BMP2 is synthesized as a 60 kDa precursor that is processed in the secretory pathway to a small 18 kDa monomer; 2 monomers then associate to form the active 30 kDa homodimer, which binds to its receptor. There is also a 40-45 kDa form of BMP2, as an amino-terminal propeptide. BMP2 can induce bone formation and regeneration during early embryonic development. It is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction.

Publikationen

Species	Application	Title
rat	WB,IHC	Biomaterials; Guided bone regeneration is promoted by the molecular events in the membrane compartment.; Authors - Alberto Turri
human	WB	Biomed Pharmacother; Bacitracin promotes osteogenic differentiation of human bone marrow mesenchymal stem cells by stimulating the bone morphogenetic protein-2/Smad axis.; Authors - Hui Li ; KD Validated
human	WB	Carbohydr Polym; A fucoidan from Nemacystus decipiens disrupts angiogenesis through targeting bone morphogenetic protein 4.; Authors - Wucheng Wang
rat	WB,IHC	Int J Nanomedicine; The Role of Tantalum Nanoparticles in Bone Regeneration Involves the BMP2/Smad4/Runx2 Signaling Pathway.; Authors - Guilan Zhang
rat	WB	Arterioscler Thromb Vasc Biol; Overexpression of c1q/tumor necrosis factor-related protein-3 promotes phosphate-induced vascular smooth muscle cell calcification both in vivo and in vitro.; Authors - Yun Zhou
rat	WB，IHC	Antioxid Redox Signal; Role of Nox4 in high calcium-induced renal oxidative stress damage and crystal deposition.; Authors - Yang Xun

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