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  • Featured Product
  • KD/KO Validated

Anillin Polyklonaler Antikörper

Anillin Polyklonal Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 13136-1-AP

Synonyme

Actin binding protein anillin, anillin, actin binding protein, ANLN, scra, Scraps

Galerie der Validierungsdaten

Geprüfte Anwendungen

Produktinformation

13136-1-AP bindet in WB, IHC, ELISA Anillin und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
In Publikationen genannte Reaktivitäthuman
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Anillin fusion protein Ag3793
Vollständiger Name anillin, actin binding protein
Berechnetes Molekulargewicht 1124 aa, 124 kDa
GenBank-ZugangsnummerBC034692
Gene symbol ANLN
Gene ID (NCBI) 54443
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Anillin, an actin-binding protein, is a conserved cleavage furrow component important for cytokinesis. The human anillin protein localizes to the nucleus during interphase, the cortex following nuclear envelope breakdown, and the cleavage furrow during cytokinesis. It interactions with at least two other furrow proteins, actin and the septins through its C-terminal PH domain and N-terminal actin-binding domain. In anillin knockdown cells, the cleavage furrow ingressed but failed to complete the ingression. Anillin has been found to be overexpressed in tumors and may serve as promising marker for pancreatic carcinoma molecular diagnostics as well as a prognostic indicator for non–small cell lung cancers.

Publikationen

SpeciesApplicationTitle
humanWB, IHC

Mol Cell Biochem

Knockdown of ANLN by lentivirus inhibits cell growth and migration in human breast cancer.

Authors - Weibing Zhou
  • KD Validated
View Article