CoraLite® Plus 647-conjugated TRAF6 Monoclonal antibody

• Featured Product
• KD/KO Validated

TRAF6 Monoclonal Antibody for

Host / Isotype

Mouse / IgG1

Reactivity

Human and More (1)

Applications

WB

Conjugate

CoraLite® Plus 647 Fluorescent Dye

Publications

1

CloneNo.

1D1E1

Cat no : CL647-66498

Synonyms

RING finger protein 85, RNF85, TRAF6

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Validation Data Gallery

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Recommended dilution

Application	Dilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Published Applications

• WB: See 1 publications below

Product Information

CL647-66498 targets TRAF6 in WB applications and shows reactivity with Human samples.

• Tested Reactivity: Human
• Cited Reactivity: human
• Host / Isotype: Mouse / IgG1
• Class: Monoclonal
• Type: Antibody
• Immunogen: TRAF6 fusion protein Ag24696
• Full Name: TNF receptor-associated factor 6
• Calculated Molecular Weight: 522 aa, 60 kDa
• Observed Molecular Weight: 60 kDa
• GenBank Accession Number: BC031052
• Gene Symbol: TRAF6
• Gene ID (NCBI): 7189
• Conjugate: CoraLite® Plus 647 Fluorescent Dye
• Excitation/Emission Maxima Wavelengths: 654 nm / 674 nm
• Form: Liquid
• Purification Method: Protein G purification
• Storage Buffer: PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
• Storage Conditions: Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage.

Background Information

TRAF6 is a member of the TNF receptor associated factor (TRAF) protein family. TRAF6 is recognized as a signal transducer, which activates the NF-κB pathway in response to pro-inflammatory cytokines. TRAF6 has E3 ligase activity and is responsible for inducing Lys-63 (K63)-linked poly-ubiquitination chains, functioning together with E2 Ubc13/Uev1A complex to mediate IKK activation TRAF6 plays a crucial role in the regulation of the innate and adaptive immune responses.

Publications

Species	Application	Title
human	WB	Balkan Med J; Asiaticoside Down-Regulates HIF-1α to Inhibit Proliferation, Migration, and Angiogenesis in Thyroid Cancer Cells; Authors - Yi Zhang