Anticorps Polyclonal de lapin anti-MEF2C

MEF2C Polyclonal Antibody for IF

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

IF

Conjugaison

CoraLite® Plus 488 Fluorescent Dye

N° de cat : CL488-20326

Synonymes

MEF2C, myocyte enhancer factor 2C

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Galerie de données de validation

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  IF Staining of mouse brain using CL488-20326

  Immunofluorescent analysis of (4% PFA) fixed mouse brain tissue using CoraLite® Plus 488 MEF2C antibody (CL488-20326) at dilution of 1:200.

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  IF Staining of mouse brain using CL488-20326

  Immunofluorescent analysis of (4% PFA) fixed mouse brain tissue using CoraLite® Plus 488 MEF2C antibody (CL488-20326) at dilution of 1:200.

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Applications testées

• Résultats positifs en IF: tissu cérébral de souris,

Dilution recommandée

• Immunofluorescence (IF): IF : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Informations sur le produit

CL488-20326 cible MEF2C dans les applications de IF et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: MEF2C Protéine recombinante Ag13255
• Nom complet: myocyte enhancer factor 2C
• Masse moléculaire calculée: 469 aa, 51 kDa
• Poids moléculaire observé: 65-68 kDa
• Numéro d’acquisition GenBank: BC026341
• Symbole du gène: MEF2C
• Identification du gène (NCBI): 4208
• Conjugaison: CoraLite® Plus 488 Fluorescent Dye
• Excitation/Emission maxima wavelengths: 493 nm / 522 nm
• Forme: Liquide
• Méthode de purification: Purifié par affinité contre l'antigène
• Tampon de stockage: PBS avec glycérol à 50 %, Proclin300 à 0,05 % et BSA à 0,5 %, pH 7,3.
• Conditions de stockage: Stocker à -20 °C. Éviter toute exposition à la lumière. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

MEF2C belongs to the MEF2 family. It is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. MEF2C controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. It plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. It is crucial for normal neuronal development, distribution, and electrical activity in the neocortex and is necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis. This protein is required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. It may also be involved in neurogenesis and in the development of cortical architecture. This antibody is a rabbit polyclonal antibody raised against an internal 161Aa region of human MEF2C.Phosphorylation and acetylation may affect the molecular weight of protein,and 60-70kd was also been reported(PMID:28973134).