Anticorps Polyclonal de lapin anti-FANCD2

• Phare
• Validé par KD/KO

FANCD2 Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IP, IF, ELISA

Conjugaison

Non conjugué

Publications

4

N° de cat : 28619-1-AP

Synonymes

DKFZp762A223, FA D2, FA4, FACD, FAD, FAD2, FANCD, FANCD2, FLJ23826, Protein FACD2

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Galerie de données de validation

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  WB analysis using 28619-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 28619-1-AP (FANCD2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: cellules HeLa, cellules K-562

Dilution recommandée

• Western Blot (WB): WB : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• KD/KO: See 1 publications below
• WB: See 3 publications below
• IF: See 1 publications below
• IP: See 1 publications below

Informations sur le produit

28619-1-AP cible FANCD2 dans les applications de WB, IP, IF, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Réactivité citée: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: FANCD2 Protéine recombinante Ag29460
• Nom complet: Fanconi anemia, complementation group D2
• Masse moléculaire calculée: 164 kDa
• Poids moléculaire observé: 150 kDa
• Numéro d’acquisition GenBank: NM_001018115
• Symbole du gène: FANCD2
• Identification du gène (NCBI): 2177
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

FANCD2, also named as FACD and FACD2, is required for maintenance of chromosomal stability. FANCD2 promotes accurate and efficient pairing of homologs during meiosis. FANCD2 is involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. It may participate in S phase and G2 phase checkpoint activation upon DNA damage. It promotes BRCA2/FANCD1 loading onto damaged chromatin. FANCD2 may also be involved in B-cell immunoglobulin isotype switching. Defects in FANCD2 are a cause of Fanconi anemia (FA) which is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies.

Publications

Species	Application	Title
human	WB	Cell Rep; C1orf112 teams up with FIGNL1 to facilitate RAD51 filament disassembly and DNA interstrand cross-link repair; Authors - Zenan Zhou
human	WB,IP	Front Pharmacol; Abnormally Expressed Ferroptosis-Associated FANCD2 in Mediating the Temozolomide Resistance and Immune Response in Glioblastoma.; Authors - Liying Song ; KD Validated
human	IF	Eur J Pharmacol; Rapid DNA interstrand cross-linking of Pt(IV) compound.; Authors - Chun-Lai Zhao
human	WB	Adv Sci (Weinh); HPV Enhances HNSCC Chemosensitization by Inhibiting SERPINB3 Expression to Disrupt the Fanconi Anemia Pathway; Authors - Zixian Huang