Anticorps Polyclonal de lapin anti-DYRK1A

DYRK1A Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, ELISA

Conjugaison

Non conjugué

N° de cat : 28607-1-AP

Synonymes

DYRK, DYRK1, DYRK1A, hMNB, HP86, MNB, MNBH

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Galerie de données de validation

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  WB analysis using 28607-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 28607-1-AP (DYRK1A antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

• 

  WB analysis of HEK-293 using 28607-1-AP

  HEK-293 cells were subjected to SDS PAGE followed by western blot with 28607-1-AP (DYRK1A antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

• 

  WB analysis of PC-3 using 28607-1-AP

  PC-3 cells were subjected to SDS PAGE followed by western blot with 28607-1-AP (DYRK1A antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: cellules PC-3, cellules HEK-293

Dilution recommandée

• Western Blot (WB): WB : 1:1000-1:4000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Informations sur le produit

28607-1-AP cible DYRK1A dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: DYRK1A Protéine recombinante Ag29433
• Nom complet: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
• Masse moléculaire calculée: 86 kDa
• Poids moléculaire observé: 70kDa, 85 kDa
• Numéro d’acquisition GenBank: NM_001396
• Symbole du gène: DYRK1A
• Identification du gène (NCBI): 1859
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome.