Anticorps Monoclonal anti-CD279 (PD-1)
CD279 (PD-1) Monoclonal Antibody for Blocking, ELISA
Hôte / Isotype
Rat / IgG2a, kappa
Réactivité testée
souris
Applications
ELISA, Blocking
Conjugaison
Non conjugué
CloneNo.
RMP1-14
N° de cat : 65288-1-Ig
Synonymes
Galerie de données de validation
Applications testées
Résultats positifs en ELISA |
Dilution recommandée
Application | Dilution |
---|---|
Test immuno-enzymatique (ELISA) | ELISA : |
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, check data in validation data gallery |
Informations sur le produit
65288-1-Ig cible CD279 (PD-1) dans les applications de ELISA, Blocking et montre une réactivité avec des échantillons souris
Réactivité | souris |
Hôte / Isotype | Rat / IgG2a, kappa |
Clonalité | Monoclonal |
Type | Anticorps |
Immunogène | Cellules BHK transfectées par PD-1 de souris |
Nom complet | programmed cell death 1 |
Numéro d’acquisition GenBank | BC119179 |
Symbole du gène | Pdcd1 |
Identification du gène (NCBI) | 18566 |
Conjugaison | Non conjugué |
Forme | Liquide |
Méthode de purification | Purification par affinité |
Tampon de stockage | PBS with 0.09% sodium azide. |
Conditions de stockage | Store at 2-8°C. Stable for one year after shipment. |
Informations générales
Programmed cell death 1 (PD-1, also known as CD279) is an immunoinhibitory receptor that belongs to the CD28/CTLA-4 subfamily of the Ig superfamily. It is a 288 amino acid (aa) type I transmembrane protein composed of one Ig superfamily domain, a stalk, a transmembrane domain, and an intracellular domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) as well as an immunoreceptor tyrosine-based switch motif (ITSM) (PMID: 18173375). PD-1 is expressed during thymic development and is induced in a variety of hematopoietic cells in the periphery by antigen receptor signaling and cytokines (PMID: 20636820). Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function (PMID: 19426218). It is critical for the regulation of T cell function during immunity and tolerance. Blockade of PD-1 can overcome immune resistance and also has been shown to have antitumor activity (PMID: 22658127; 23169436). RMP1-14 is a monoclonal antibody that targets the murine PD-1 protein and can be used in mouse models to block the reaction between PD-1 and PD-L1/PD-L2 (PMID: 14764726; 31832706).