Anticorps Monoclonal anti-CD279 (PD-1)

CD279 (PD-1) Monoclonal Antibody for Blocking, ELISA

Hôte / Isotype

Rat / IgG2a, kappa

Réactivité testée

souris

Applications

ELISA, Blocking

Conjugaison

Non conjugué

CloneNo.

RMP1-14

N° de cat : 65288-1-Ig

Synonymes

Ly101, PD 1, Pdc1, Pdcd1, programmed cell death 1



Applications testées

Résultats positifs en ELISA

Dilution recommandée

ApplicationDilution
Test immuno-enzymatique (ELISA)ELISA :
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

65288-1-Ig cible CD279 (PD-1) dans les applications de ELISA, Blocking et montre une réactivité avec des échantillons souris

Réactivité souris
Hôte / Isotype Rat / IgG2a, kappa
Clonalité Monoclonal
Type Anticorps
Immunogène Cellules BHK transfectées par PD-1 de souris
Nom complet programmed cell death 1
Numéro d’acquisition GenBankBC119179
Symbole du gène Pdcd1
Identification du gène (NCBI) 18566
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité
Tampon de stockage PBS with 0.09% sodium azide.
Conditions de stockageStore at 2-8°C. Stable for one year after shipment.

Informations générales

Programmed cell death 1 (PD-1, also known as CD279) is an immunoinhibitory receptor that belongs to the CD28/CTLA-4 subfamily of the Ig superfamily. It is a 288 amino acid (aa) type I transmembrane protein composed of one Ig superfamily domain, a stalk, a transmembrane domain, and an intracellular domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) as well as an immunoreceptor tyrosine-based switch motif (ITSM) (PMID: 18173375). PD-1 is expressed during thymic development and is induced in a variety of hematopoietic cells in the periphery by antigen receptor signaling and cytokines (PMID: 20636820). Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function (PMID: 19426218). It is critical for the regulation of T cell function during immunity and tolerance. Blockade of PD-1 can overcome immune resistance and also has been shown to have antitumor activity (PMID: 22658127; 23169436). RMP1-14 is a monoclonal antibody that targets the murine PD-1 protein and can be used in mouse models to block the reaction between PD-1 and PD-L1/PD-L2 (PMID: 14764726; 31832706).