Anticorps Monoclonal anti-PD-1/CD279
PD-1/CD279 Monoclonal Antibody for FC
Hôte / Isotype
Mouse / IgG1
Réactivité testée
Humain
Applications
FC
Conjugaison
Non conjugué
CloneNo.
J110
N° de cat : 65119-1-Ig
Synonymes
Galerie de données de validation
Applications testées
Résultats positifs en cytométrie | lymphocytes de sang périphérique humain, |
Dilution recommandée
Application | Dilution |
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This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, check data in validation data gallery |
Informations sur le produit
65119-1-Ig cible PD-1/CD279 dans les applications de FC et montre une réactivité avec des échantillons Humain
Réactivité | Humain |
Hôte / Isotype | Mouse / IgG1 |
Clonalité | Monoclonal |
Type | Anticorps |
Immunogène | s/o |
Nom complet | programmed cell death 1 |
Masse moléculaire calculée | 288 aa, 32 kDa |
Numéro d’acquisition GenBank | BC074740 |
Symbole du gène | PDCD1 |
Identification du gène (NCBI) | 5133 |
Conjugaison | Non conjugué |
Forme | Liquide |
Méthode de purification | Purification par affinité |
Tampon de stockage | PBS avec azoture de sodium à 0,1 %, pH 7,3. |
Conditions de stockage | Store at 2-8°C. Stable for one year after shipment. |
Informations générales
Programmed cell death 1 (PD-1, also known as CD279) is an immunoinhibitory receptor that belongs to the CD28/CTLA-4 subfamily of the Ig superfamily. It is a 288 amino acid (aa) type I transmembrane protein composed of one Ig superfamily domain, a stalk, a transmembrane domain, and an intracellular domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) as well as an immunoreceptor tyrosine-based switch motif (ITSM) (PMID: 18173375). PD-1 is expressed during thymic development and is induced in a variety of hematopoietic cells in the periphery by antigen receptor signaling and cytokines (PMID: 20636820). Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function (PMID: 19426218). It is critical for the regulation of T cell function during immunity and tolerance. Blockade of PD-1 can overcome immune resistance and also has been shown to have antitumor activity (PMID: 22658127; 23169436).
Protocole
Product Specific Protocols | |
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FC protocol for PD-1/CD279 antibody 65119-1-Ig | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |