Anticorps Monoclonal anti-PD-1/CD279

PD-1/CD279 Monoclonal Antibody for FC

Hôte / Isotype

Mouse / IgG1, kappa

Réactivité testée

Humain, primates non humains

Applications

FC

Conjugaison

Non conjugué

CloneNo.

EH12.2H7

N° de cat : 65168-1-Ig

Synonymes

CD279, hPD 1, hPD l, PD1, PDCD1, programmed cell death 1, Protein PD 1, SLEB2



Applications testées

Résultats positifs en cytométriePHA treated human PBMCs,

Dilution recommandée

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

65168-1-Ig cible PD-1/CD279 dans les applications de FC et montre une réactivité avec des échantillons Humain, primates non humains

Réactivité Humain, primates non humains
Hôte / Isotype Mouse / IgG1, kappa
Clonalité Monoclonal
Type Anticorps
Immunogène Recombinant human CD279 protein
Nom complet programmed cell death 1
Masse moléculaire calculée 288 aa, 32 kDa
Numéro d’acquisition GenBankBC074740
Symbole du gène PDCD1
Identification du gène (NCBI) 5133
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purifié par chromatographie d'affinité par protéine A
Tampon de stockage PBS with 0.09% sodium azide.
Conditions de stockageStore at 2-8°C. Stable for one year after shipment.

Informations générales

Programmed cell death 1 (PD-1, also known as CD279) is an immunoinhibitory receptor that belongs to the CD28/CTLA-4 subfamily of the Ig superfamily. It is a 288 amino acid (aa) type I transmembrane protein composed of one Ig superfamily domain, a stalk, a transmembrane domain, and an intracellular domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) as well as an immunoreceptor tyrosine-based switch motif (ITSM) (PMID: 18173375). PD-1 is expressed during thymic development and is induced in a variety of hematopoietic cells in the periphery by antigen receptor signaling and cytokines (PMID: 20636820). Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function (PMID: 19426218). It is critical for the regulation of T cell function during immunity and tolerance. Blockade of PD-1 can overcome immune resistance and also has been shown to have antitumor activity (PMID: 22658127; 23169436).

Protocole

Product Specific Protocols
FC protocol for PD-1/CD279 antibody 65168-1-IgDownload protocol
Standard Protocols
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