Anticorps Monoclonal anti-CD244

CD244 Monoclonal Antibody for FC

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

2B4.69

N° de cat : 65270-1-Ig

Synonymes

2B4, CD244, h2B4, NAIL, NKR2B4, SLAMF4

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Galerie de données de validation

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  FC experiment of human PBMCs using 65270-1-Ig

  1X10^6 human PBMCs were surface co-stained with CL750 Anti-Human CD56 and 0.2 ug Anti-Human CD244 (65270-1-Ig, Clone:2B4.69) and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L) at dilution 1:1000, or Mouse IgG1 Isotype Control. Cells were not fixed. Lymphocytes were gated.

• 

  FC experiment of human PBMCs using 65270-1-Ig

  1X10^6 human PBMCs were surface stained with 0.2 ug Anti-Human CD244 (65270-1-Ig, Clone:2B4.69) and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L) at dilution 1:1000, or Mouse IgG1 Isotype Control. Cells were not fixed. Lymphocytes were gated.

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Applications testées

• Résultats positifs en cytométrie: CMSP humaines,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

65270-1-Ig cible CD244 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: s/o
• Nom complet: CD244 molecule, natural killer cell receptor 2B4
• Numéro d’acquisition GenBank: BC028073
• Symbole du gène: CD244
• Identification du gène (NCBI): 51744
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité
• Tampon de stockage: PBS with 0.09% sodium azide.
• Conditions de stockage: 2-8°C.

Informations générales

CD244, also known as SLAMF4 or 2B4, is a type I transmembrane glycoprotein belonging to the signaling lymphocyte activation molecule (SLAM) family. It consists of an extracellular segment with two immunoglobulin (Ig)-like domains, a transmembrane region, and a cytoplasmic domain containing tyrosine-based motifs (PMID: 9841922; 30546369). CD244 is present on natural killer (NK) cells, γδ T cells, a subset of CD8+ T cells, monocytes, basophils, dendritic cells, and myeloid-derived suppressor cells (MDSCs) (PMID: 30546369). It binds to CD48 with high affinity and transmits stimulatory or inhibitory signals that regulate immune function (PMID: 9841922; 18523281).