Anticorps Monoclonal anti-CD223
CD223 Monoclonal Antibody for FC
Hôte / Isotype
Rat / IgG1, kappa
Réactivité testée
souris
Applications
FC
Conjugaison
PE Fluorescent Dye
CloneNo.
C9B7W
N° de cat : PE-65098
Synonymes
Galerie de données de validation
Applications testées
Résultats positifs en cytométrie | anti-CD3/CD28 stimulated mouse splenocytes |
Dilution recommandée
Application | Dilution |
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This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, check data in validation data gallery |
Informations sur le produit
PE-65098 cible CD223 dans les applications de FC et montre une réactivité avec des échantillons souris
Réactivité | souris |
Hôte / Isotype | Rat / IgG1, kappa |
Clonalité | Monoclonal |
Type | Anticorps |
Immunogène | Protéine de fusion CD223-Ig murine |
Nom complet | lymphocyte-activation gene 3 |
Numéro d’acquisition GenBank | BC120591 |
Symbole du gène | Lag3 |
Identification du gène (NCBI) | 16768 |
Conjugaison | PE Fluorescent Dye |
Excitation/Emission maxima wavelengths | 496 nm, 565 nm / 578 nm |
Forme | Liquide |
Méthode de purification | Purification par affinité |
Tampon de stockage | PBS with 0.1% sodium azide and 0.5% BSA. |
Conditions de stockage | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
Informations générales
Lymphocyte activation gene 3 protein (LAG-3), also known as CD223, is a type I transmembrane protein belonging to the immunoglobulin superfamily (PMID: 1692078). It is a CD4-related molecule that binds MHC class II with high affinity (PMID: 1692078; 9159144). LAG-3 is expressed on activated T and NK cells. Besides, natural CD4(+)CD25(+) Tregs express LAG-3 upon activation (PMID: 15485628). LAG-3 negatively regulates T-cell function and homeostasis, and contributes to the suppressor activity of Tregs (PMID: 14644131; 15485628).
Protocole
Product Specific Protocols | |
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FC protocol for PE CD223 antibody PE-65098 | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |