Anticorps Monoclonal anti-CD134

CD134 Monoclonal Antibody for FC

Hôte / Isotype

Rat / IgG1, kappa

Réactivité testée

souris

Applications

FC

Conjugaison

APC Fluorescent Dye

CloneNo.

OX-86

N° de cat : APC-65136

Synonymes

ACT35, CD134, Ly 70, Ox40, Tnfrsf4, Txgp1, TXGP1L

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Galerie de données de validation

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  FC experiment of BALB/C mouse splenocytes using APC-65136

  1X10^6 unstimulated or anti-CD3/CD28 stimulated (2 days) mouse splenocytes were surface co-stained with FITC Plus Anti-Mouse CD3 (17A2) (FITC-65077, Clone: 17A2) and 0.2 ug APC Anti-Mouse CD134 (APC-65136, Clone: OX-86). Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: Anti-CD3/CD28 treated mouse splenocytes

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

APC-65136 cible CD134 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Rat / IgG1, kappa
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: Protéine chimérique OX-40-CD4 recombinante de souris
• Nom complet: tumor necrosis factor receptor superfamily, member 4
• Numéro d’acquisition GenBank: BC065782
• Symbole du gène: Tnfrsf4
• Identification du gène (NCBI): 22163
• Conjugaison: APC Fluorescent Dye
• Excitation/Emission maxima wavelengths: 650 nm / 660 nm
• Forme: Liquide
• Méthode de purification: Purification par affinité
• Tampon de stockage: PBS with 0.1% sodium azide and 0.5% BSA.
• Conditions de stockage: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Informations générales

CD134, also known as OX40 and TNFRSF4, is a member of the TNFR-superfamily of receptors (PMID: 2828930; 9766631). It is a type I transmembrane protein predominantly expressed on activated T cells which include CD4 and CD8 T cells, Th2, Th1, and Th17 cells, as well as regulatory T cells (Tregs) (PMID: 20307208). CD134 is activated by its cognate ligand CD134L (OX40L) and functions as a T cell co-stimulatory molecule (PMID: 26215166). CD134-CD134L interactions have been proposed as a potential therapeutic target for treating autoimmune diseases, cancer and infectious disease (PMID: 26215166; 19426222).