Anticorps Monoclonal anti-CD11c

CD11c Monoclonal Antibody for FC

Hôte / Isotype

Armenian Hamster / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

N418

N° de cat : 65130-1-Ig

Synonymes

AI449405, Cd11c, Cr4, integrin alpha X, Itgax, N418

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Galerie de données de validation

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  FC experiment of C57BL/6 mouse splenocytes using 65130-1-Ig

  1X10^6 C57BL/6 mouse splenocytes were surface co-stained with APC Anti-Mouse MHC Class II (I-A/I-E) (M5/114.15.2) and 0.5 ug Anti-Mouse CD11c (65130-1-Ig, Clone:N418) and FITC anti-Armenian Hamster IgG Antibody at dilution 1:100, or 0.5 ug Armenian Hamster IgG Isotype Control (PIP) and FITC anti-Armenian Hamster IgG Antibody at dilution 1:100. Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: C57BL/6 mouse splenocytes,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

65130-1-Ig cible CD11c dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Armenian Hamster / IgG
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: Cellules dendritiques de rate de souris
• Nom complet: integrin alpha X
• Numéro d’acquisition GenBank: BC167225
• Symbole du gène: Itgax
• Identification du gène (NCBI): 16411
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide.
• Conditions de stockage: Store at 2-8°C. Stable for one year after shipment.

Informations générales

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11c, also known as integrin αX, is a type I transmembrane glycoprotein present on a variety of cells, including monocytes/macrophages, granulocytes, a subset of B cells, NK cells and dendritic cells (PMID: 2897326; 1680915; 1694698; 17389580). As a result of its high level of expression on most dendritic cells, CD11c is typically considered to be a marker of conventional dendritic cells (PMID: 27119555). CD11c forms an α/β heterodimer with CD18 (integrin β2). CD11c/CD18 acts a receptor for fibrinogen and is important in monocyte adhesion and chemotaxis (PMID: 1671533).