Anticorps Monoclonal anti-CD11b

CD11b Monoclonal Antibody for FC

Hôte / Isotype

Rat / IgG2b, kappa

Réactivité testée

Humain, souris

Applications

IF, FC

Conjugaison

Non conjugué

Publications

2

CloneNo.

M1/70

N° de cat : 65055-1-Ig

Synonymes

CD11b, CD11b/CD18, CR3, CR3A, F730045J24Rik, integrin alpha M, Itgam, Ly 40, Mac 1, Mac 1a, MAC1

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Galerie de données de validation

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  FC experiment of mouse bone marrow cells using 65055-1-Ig

  1X10^6 mouse bone marrow cells were surface stained with 0.2 ug Anti-Mouse CD11b (65055-1-Ig, Clone: M1/70) or 0.2 ug Isotype Control. Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: cellules médullaires de souris,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Applications publiées

• IF: See 1 publications below
• FC: See 1 publications below

Informations sur le produit

65055-1-Ig cible CD11b dans les applications de IF, FC et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Réactivité citée: souris
• Hôte / Isotype: Rat / IgG2b, kappa
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: Lymphocytes T spléniques de souris C57BL/10 et splénocytes C57BL/10 activés par la concanavaline A
• Nom complet: integrin alpha M
• Numéro d’acquisition GenBank: BC156991
• Symbole du gène: Itgam
• Identification du gène (NCBI): 16409
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité
• Tampon de stockage: PBS with 0.09% sodium azide.
• Conditions de stockage: Store at 2-8°C. Stable for one year after shipment.

Informations générales

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11b, also known as Integrin alpha M or CR3A, belongs to the integrin alpha chain family. CD11b forms an α/β heterodimer with CD18 (integrin β2). CD11b/CD18 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PMID: 9558116; 20008295). CD11b/CD18 is a receptor for the complement protein fragment iC3b, and is also a receptor for fibrinogen, factor X and ICAM1 (PMID: 2971974; 15485828).

Publications

Species	Application	Title
mouse	FC	Nanoscale Adv; Bacteria-mediated tumor immunotherapy via photothermally-programmed PD1 expression; Authors - Wenxuan Xu
mouse	IF	Eur J Pharmacol; Complanatuside A improves functional recovery after spinal cord injury through inhibiting JNK signaling-mediated microglial activation; Authors - Yibo Xu