Thyroglobulin Monoklonaler Antikörper

Thyroglobulin Monoklonal Antikörper für IF

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human

Anwendung

IF

Konjugation

CoraLite®594 Fluorescent Dye

CloneNo.

4D3C5

Kat-Nr. : CL594-60272

Synonyme

AITD3, TG, TGN, thyroglobulin

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Galerie der Validierungsdaten

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  IF Staining of human thyroid cancer using CL594-60272

  Immunofluorescent analysis of (4% PFA) fixed human thyroid cancer tissue using CoraLite®594 Thyroglobulin antibody (CL594-60272, Clone: 4D3C5 ) at dilution of 1:200.

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  IF Staining of human thyroid cancer using CL594-60272

  Immunofluorescent analysis of (4% PFA) fixed human thyroid cancer tissue using CoraLite®594 Thyroglobulin antibody (CL594-60272, Clone: 4D3C5 ) at dilution of 1:200.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in IF: humanes Schilddrüsenkarzinomgewebe

Empfohlene Verdünnung

• Immunfluoreszenz (IF): IF : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Produktinformation

CL594-60272 bindet in IF Thyroglobulin und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Maus / IgG2a
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: Thyroglobulin fusion protein Ag18070
• Vollständiger Name: thyroglobulin
• Berechnetes Molekulargewicht: 2768 aa, 305 kDa
• GenBank-Zugangsnummer: BC140933
• Gene symbol: TG
• Gene ID (NCBI): 7038
• Konjugation: CoraLite®594 Fluorescent Dye
• Excitation/Emission maxima wavelengths: 588 nm / 604 nm
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: BS mit 50% Glyzerin, 0,05% Proclin300, 0,5% BSA, pH 7,3.
• Lagerungsbedingungen: Bei -20°C lagern. Vor Licht schützen. Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.