DR3 Polyklonaler Antikörper

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• KD/KO Validated

DR3 Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

Publikationen

2

Kat-Nr. : 55397-1-AP

Synonyme

APO 3, APO3, DDR3, Death receptor 3, DR3, LARD, Protein WSL, Protein WSL 1, TNFRSF12, TNFRSF25, TR3, TRAMP, WSL, WSL 1, WSL LR, WSL1

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Galerie der Validierungsdaten

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  WB analysis of PC-3 using 55397-1-AP

  WB result of DR3 antibody (55397-1-AP; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-DR3 transfected PC-3 cells.

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  WB analysis using 55397-1-AP

  PC-3 cells were subjected to SDS PAGE followed by western blot with 55397-1-AP (DR3 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

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  WB analysis of mouse spleen using 55397-1-AP

  mouse spleen tissue were subjected to SDS PAGE followed by western blot with 55397-1-AP (DR3 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

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  WB analysis of mouse thymus using 55397-1-AP

  mouse thymus tissue were subjected to SDS PAGE followed by western blot with 55397-1-AP (DR3 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: PC-3-Zellen, Mausmilzgewebe, Maus-Thymusgewebe

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:500-1:3000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• WB: See 2 publications below

Produktinformation

55397-1-AP bindet in WB, ELISA DR3 und zeigt Reaktivität mit human, Maus

• Getestete Reaktivität: human, Maus
• In Publikationen genannte Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: Peptid
• Vollständiger Name: tumor necrosis factor receptor superfamily, member 25
• Berechnetes Molekulargewicht: 46 kDa
• Beobachtetes Molekulargewicht: 52 kDa, 17-20 kDa
• GenBank-Zugangsnummer: NM_003790
• Gene symbol: TNFRSF25
• Gene ID (NCBI): 8718
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TNFRSF25, also named as APO3, DDR3, DR3, TNFRSF12, WSL, WSL1, LARD, TRAMP and AIR, is a receptor for TNFSF12/APO3L/TWEAK. TNFRSF25 interacts directly with the adapter TRADD. It mediates activation of NF-kappa-B and induces apoptosis. TNFRSF25 may play a role in regulating lymphocyte homeostasis. It is constitutively and highly expressed by CD4(+)FoxP3(+) Tregs. This antibody can recognize all the isoform of TNFRSF25.

Publikationen

Species	Application	Title
mouse	WB	Life Sci; TL1A primed dendritic cells activation exacerbated chronic murine colitis.; Authors - Fei Han
human,mouse	WB	Exp Biol Med (Maywood); Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer; Authors - Wei Wang

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