TDP-43 (C-terminal) Monoklonaler Antikörper

TDP-43 (C-terminal) Monoklonal Antikörper für IF

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human, Maus, Ratte

Anwendung

IF

Konjugation

CoraLite® Plus 488 Fluorescent Dye

CloneNo.

1G5F6

Kat-Nr. : CL488-67345

Synonyme

ALS10, TAR DNA binding protein, TAR DNA binding protein 43, TARDBP, TDP 43, TDP43

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Galerie der Validierungsdaten

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  IF Staining of rat brain using CL488-67345

  Immunofluorescent analysis of (4% PFA) fixed rat brain tissue using CoraLite® Plus 488-conjugated TDP-43 (C-terminal) antibody (CL488-67345, Clone: 1G5F6 ) at dilution of 1:300.

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  IF Staining of rat brain using CL488-67345

  Immunofluorescent analysis of (4% PFA) fixed rat brain tissue using CoraLite® Plus 488-conjugated TDP-43 (C-terminal) antibody (CL488-67345, Clone: 1G5F6 ) at dilution of 1:300.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in IF: Rattenhirngewebe

Empfohlene Verdünnung

• Immunfluoreszenz (IF): IF : 1:150-1:600

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Produktinformation

CL488-67345 bindet in IF TDP-43 (C-terminal) und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Maus / IgG2a
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: Peptid
• Vollständiger Name: TAR DNA binding protein
• Berechnetes Molekulargewicht: 43 kDa
• Beobachtetes Molekulargewicht: 43-45 kDa
• GenBank-Zugangsnummer: NM_007375
• Gene symbol: TARDBP
• Gene ID (NCBI): 23435
• Konjugation: CoraLite® Plus 488 Fluorescent Dye
• Excitation/Emission maxima wavelengths: 493 nm / 522 nm
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: BS mit 50% Glyzerin, 0,05% Proclin300, 0,5% BSA, pH 7,3.
• Lagerungsbedingungen: Bei -20°C lagern. Vor Licht schützen. Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Transactivation response (TAR), DNA-binding protein of 43 kDa (also known as TARDBP or TDP-43), was first isolated as a transcriptional inactivator binding to the TAR DNA element of the HIV-1 virus. Neumann et al. (2006) found that a hyperphosphorylated, ubiquitinated, and cleaved form of TARDBP, known as pathologic TDP-43, is the major component of the tau-negative and ubiquitin-positive inclusions that characterize amyotrophic lateral sclerosis (ALS) and the most common pathological subtype of frontotemporal lobar degeneration (FTLD-U). 67345-1-Ig is a mouse monoclonal antibody raised against the C-terminal region of human TDP-43.