SPTBN2 Polyklonaler Antikörper

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• KD/KO Validated

SPTBN2 Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte und mehr (1)

Anwendung

WB, IF, ELISA

Konjugation

Unkonjugiert

Publikationen

5

Kat-Nr. : 55107-1-AP

Synonyme

Beta III spectrin, SCA5, Spectrin beta chain, brain 2, Spectrin beta-3, SPTBN2

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Galerie der Validierungsdaten

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  WB analysis using 55107-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 55107-1-AP (SPTBN2 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

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  WB analysis of human brain using 55107-1-AP

  human brain tissue were subjected to SDS PAGE followed by western blot with 55107-1-AP (SPTBN2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: HeLa-Zellen, humanes Hirngewebe

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:500-1:3000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 1 publications below
• WB: See 5 publications below
• IF: See 1 publications below

Produktinformation

55107-1-AP bindet in WB, IF, ELISA SPTBN2 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• In Publikationen genannte Reaktivität: human, drosophila, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: Peptid
• Vollständiger Name: spectrin, beta, non-erythrocytic 2
• Berechnetes Molekulargewicht: 271 kDa
• Beobachtetes Molekulargewicht: 270 kDa
• GenBank-Zugangsnummer: NM_006946
• Gene symbol: SPTBN2
• Gene ID (NCBI): 6712
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: 0,1 M NaHCO3, 0,1M Glyzin, 0,02% Natriumazid und 50% Glyzerin, pH 7,3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SPTBN2, also named as KIAA0302, belongs to the spectrin family. It probably plays an important role in neuronal membrane skeleton. Defects in SPTBN2 are the cause of spinocerebellar ataxia type 5 (SCA5). The antibody is specific to SPTBN2.

Publikationen

Species	Application	Title
Drosophila	WB, IF	J Biol Chem; β-Spectrin regulates the Hippo signaling pathway and modulates the basal actin network.; Authors - Kenneth Kin Lam Wong ; KD Validated
mouse	WB	Front Mol Neurosci; Analyzing the mechanisms that facilitate the subtype-specific assembly of γ-aminobutyric acid type A receptors; Authors - Catherine Choi
mouse	WB	Cerebellum; Nitric Oxide Critically Regulates Purkinje Neuron Dendritic Development Through a Metabotropic Glutamate Receptor Type 1-Mediated Mechanism.; Authors - Vasiliki Tellios
human	WB	Dis Markers; SPTBN2 Promotes the Progression of Thyroid Cancer by Accelerating G1/S Transition and Inhibiting Apoptosis; Authors - Xiaofen Zhou
human	WB	Exp Ther Med; Decreased SPTBN2 expression regulated by the ceRNA network is associated with poor prognosis and immune infiltration in low‑grade glioma; Authors - Guo-Rong Chen