SLMAP Polyklonaler Antikörper

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• KD/KO Validated

SLMAP Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

Publikationen

1

Kat-Nr. : 25220-1-AP

Synonyme

KIAA1601, sarcolemma associated protein, Sarcolemmal associated protein, SLAP, SLMAP

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Galerie der Validierungsdaten

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  WB analysis of mouse heart using 25220-1-AP

  mouse heart tissue were subjected to SDS PAGE followed by western blot with 25220-1-AP (SLMAP Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

• 

  WB analysis of mouse skeletal muscle using 25220-1-AP

  mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 25220-1-AP (SLMAP Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

• 

  WB analysis of A431 using 25220-1-AP

  A431 cells were subjected to SDS PAGE followed by western blot with 25220-1-AP (SLMAP Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: Mausherzgewebe, A431-Zellen, Maus-Skelettmuskelgewebe

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:500-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 1 publications below
• WB: See 1 publications below

Produktinformation

25220-1-AP bindet in WB, ELISA SLMAP und zeigt Reaktivität mit human, Maus

• Getestete Reaktivität: human, Maus
• In Publikationen genannte Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: SLMAP fusion protein Ag18162
• Vollständiger Name: sarcolemma associated protein
• Berechnetes Molekulargewicht: 828 aa, 95 kDa
• Beobachtetes Molekulargewicht: 35 kDa, 45 kDa, 63-66 kDa, 83-91 kDa
• GenBank-Zugangsnummer: BC115701
• Gene symbol: SLMAP
• Gene ID (NCBI): 7871
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Sarcolemmal membrane associated protein (SLMAP) is a tail-anchored membrane protein involved in the docking and membrane fusion process via protein-protein interactions. Deregulation of SLMAP expression plays an important role in type 2 diabetes, and changes in SLMAP expression are linked to hyperglycemia and diabetes. SLMAPs are components of cardiac membranes and have been identified as a novel regulator of cardiac function. There are several isoforms of SLMAPs with varying molecular size (35, 45, 63, and 83-91 kDa) as a result of alternative splicing. The short 35-kDa isoform is predominantly expressed in cardiac and slow-twitch skeletal muscle, while the 83- to 91-kDa isoform is ubiquitous. This antibody recognizes all of these isoforms in mouse heart lysate. (21785580, 22180652)

Publikationen

Species	Application	Title
human	WB	Thorac Cancer; Tumor suppressor effect of an antibody on xenotransplanted sarcomatoid mesothelioma cells; Authors - Masayoshi Hasegawa ; KD Validated