RSPO2 Polyklonaler Antikörper

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• KD/KO Validated

RSPO2 Polyklonal Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte und mehr (1)

Anwendung

WB, IHC, IF, ELISA

Konjugation

Unkonjugiert

Publikationen

8

Rezensionen (1)

Kat-Nr. : 17781-1-AP

Synonyme

CRISTIN2, hRspo2, R spondin 2, Roof plate specific spondin 2, RSPO2

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Galerie der Validierungsdaten

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Geprüfte Anwendungen

Empfohlene Verdünnung

Anwendung	Verdünnung
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 2 publications below
• WB: See 7 publications below
• IHC: See 2 publications below
• IF: See 3 publications below

Produktinformation

17781-1-AP bindet in WB, IHC, IF, ELISA RSPO2 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• In Publikationen genannte Reaktivität: human, Hausschwein, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: RSPO2 fusion protein Ag11216
• Vollständiger Name: R-spondin 2 homolog (Xenopus laevis)
• Berechnetes Molekulargewicht: 243 aa, 28 kDa
• Beobachtetes Molekulargewicht: 33 kDa
• GenBank-Zugangsnummer: BC027938
• Gene symbol: RSPO2
• Gene ID (NCBI): 340419
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

RSPO2 is one of the R-spondins (RSPOs) which comprise a family of four secreted proteins that have important roles in cell proliferation, cell fate determination and organogenesis. RSPOs typically exert their effects by potentiating the Wnt/beta-catenin signaling pathway. Overexpression of Rspo2 is sufficient to promote bone morphogenetic protein-induced mineralization Rspo2 was identified as a novel common integration site (CIS) for the mouse mammary tumor virus (MMTV) in viral induced mouse mammary tumors.

Publikationen

Species	Application	Title
human,mouse	WB,IF	Cardiovasc Res; Role of R-spondin 2 in arterial lymphangiogenesis and atherosclerosis.; Authors - Bhupesh Singla
mouse	WB,IF	Int J Mol Sci; R-Spondin2, a Positive Canonical WNT Signaling Regulator, Controls the Expansion and Differentiation of Distal Lung Epithelial Stem/Progenitor Cells in Mice.; Authors - Ahmed A Raslan
human	WB,IHC	J Cancer; miR-497-5p-RSPO2 axis inhibits cell growth and metastasis in glioblastoma.; Authors - Kun Chen
human	WB	DNA Cell Biol; Expression and Prognostic Values of the Roof Plate-Specific Spondin Family in Bladder Cancer.; Authors - Lei Gao
human	WB	Mol Biol Rep; RSPO fusion transcripts in colorectal cancer in Japanese population.; Authors - Kazuya Shinmura
mouse	IF	BMC Res Notes; R-spondin 2 mediates neutrophil egress into the alveolar space through increased lung permeability.; Authors - S R Jackson ; KO Validated

Rezensionen

The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.

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FH

Marc (Verified Customer) (02-14-2023)

Used this antibody for immunofluorescence, but since the expression of this protein in spinal cord is low we used it together with a tyramide amplification kit. In this way, it works very good.

• Applications: Immunofluorescence
• Primary Antibody Dilution: 1:500
• Cell Tissue Type: Spinal Cord