PLA2R1 Polyklonaler Antikörper

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• KD/KO Validated

PLA2R1 Polyklonal Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB,ELISA

Konjugation

Unkonjugiert

Publikationen

1

Kat-Nr. : 18798-1-AP

Synonyme

CLEC13C, M type receptor, PLA2 R, PLA2G1R, PLA2IR, PLA2R, PLA2R1, Soluble PLA2 R, Soluble PLA2R

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Galerie der Validierungsdaten

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  IHC staining of human pancreas using 18798-1-AP

  Immunohistochemical analysis of paraffin-embedded human pancreas tissue slide using 18798-1-AP (PLA2R1 Antibody) at dilution of 1:100 (under 10x lens).

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  IHC staining of human pancreas using 18798-1-AP

  Immunohistochemical analysis of paraffin-embedded human pancreas tissue slide using 18798-1-AP (PLA2R1 Antibody) at dilution of 1:100 (under 40x lens).

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Geprüfte Anwendungen

Empfohlene Verdünnung

Anwendung	Verdünnung
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 1 publications below
• WB: See 1 publications below

Produktinformation

18798-1-AP bindet in WB,ELISA PLA2R1 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• In Publikationen genannte Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: Peptid
• Vollständiger Name: phospholipase A2 receptor 1, 180kDa
• Berechnetes Molekulargewicht: 168 kDa
• GenBank-Zugangsnummer: BC144631
• Gene symbol: PLA2R1
• Gene ID (NCBI): 22925
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Secretory phospholipase A2 (sPLA2) are implicated in a number of crucial physiological and pathological processes in mammals. Different types of membrane receptors for sPLA2s have been identified. The M-type receptor, PLA2R1 (phospholipase A2 receptor 1, 180 kDa), is a type I transmembrane glycoprotein containing extracellularly a cysteine-rich domain, a fibronectin type II domain and eight carbohydrate-recognition domains. It is a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. It is also able to bind to snake PA2-like toxins. PLA2R1 may be involved in responses in proinflammatory cytokine productions during endotoxic shock. It also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. It has been recently shown that PLA2R1 is the major target antigen in idiopathic membranous nephropathy (iMN). Patients with iMN have antibodies against a conformation-dependent epitope in PLA2R1.

Publikationen

Species	Application	Title
human	WB	Mol Pharm; Role of the Phospholipase A2 Receptor in Liposome Drug Delivery in Prostate Cancer Cells.; Authors - N D Quach ; KD Validated