PARK2/Parkin Polyklonaler Antikörper

• Featured Product
• KD/KO Validated

PARK2/Parkin Polyklonal Antikörper für IF

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

IF

Konjugation

CoraLite® Plus 488 Fluorescent Dye

Kat-Nr. : CL488-14060

Synonyme

AR JP, LPRS2, PARK2, Parkinson disease protein 2, PDJ, PRKN

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Galerie der Validierungsdaten

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  IF Staining of mouse heart using CL488-14060

  Immunofluorescent analysis of (4% PFA) fixed mouse heart tissue using CoraLite® Plus 488 PARK2/Parkin antibody (CL488-14060) at dilution of 1:200.

• 

  IF Staining of mouse heart using CL488-14060

  Immunofluorescent analysis of (4% PFA) fixed mouse heart tissue using CoraLite® Plus 488 PARK2/Parkin antibody (CL488-14060) at dilution of 1:200.

• 

  IF Staining of mouse brain using CL488-14060

  Immunofluorescent analysis of (4% PFA) fixed mouse brain tissue using CoraLite® Plus 488 PARK2/Parkin antibody (CL488-14060) at dilution of 1:200.

• 

  IF Staining of mouse brain using CL488-14060

  Immunofluorescent analysis of (4% PFA) fixed mouse brain tissue using CoraLite® Plus 488 PARK2/Parkin antibody (CL488-14060) at dilution of 1:200.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in IF: Mausherzgewebe, Maushirngewebe

Empfohlene Verdünnung

• Immunfluoreszenz (IF): IF : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Produktinformation

CL488-14060 bindet in IF PARK2/Parkin und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: PARK2/Parkin fusion protein Ag5092
• Vollständiger Name: Parkinson disease (autosomal recessive, juvenile) 2, parkin
• Berechnetes Molekulargewicht: 52 kDa
• Beobachtetes Molekulargewicht: 42-52 kDa
• GenBank-Zugangsnummer: BC022014
• Gene symbol: PARK2
• Gene ID (NCBI): 5071
• Konjugation: CoraLite® Plus 488 Fluorescent Dye
• Excitation/Emission maxima wavelengths: 493 nm / 522 nm
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: BS mit 50% Glyzerin, 0,05% Proclin300, 0,5% BSA, pH 7,3.
• Lagerungsbedingungen: Bei -20°C lagern. Vor Licht schützen. Nach dem Versand ein Jahr stabil. Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Parkin, a RING-type E3 ubiquitin-protein ligase, is involved in the ubiquitination pathway and contributes to protection from neurotoxicity induced by unfolded protein stresses. Its ubiquitin-protein ligase activity promotes the degradation of a variety of proteins including itself. Mutations in Parkin are implicated in the pathogenesis of autosomal recessive familial Parkinson's disease. It has 8 isoforms produced by alternative splicing.