NR1H2 Polyklonaler Antikörper

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• KD/KO Validated

NR1H2 Polyklonal Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IP, IF,ELISA

Konjugation

Unkonjugiert

Publikationen

9

Kat-Nr. : 14278-1-AP

Synonyme

Liver X receptor beta, LXR b, LXRB, NER, NER I, NR1H2, Nuclear receptor NER, Oxysterols receptor LXR beta, RIP15, UNR

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Galerie der Validierungsdaten

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  WB analysis of mouse liver using 14278-1-AP

  mouse liver tissue were subjected to SDS PAGE followed by western blot with 14278-1-AP (NR1H2 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

Empfohlene Verdünnung

Anwendung	Verdünnung
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 2 publications below
• WB: See 9 publications below
• IF: See 1 publications below
• IP: See 1 publications below

Produktinformation

14278-1-AP bindet in WB, IP, IF,ELISA NR1H2 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• In Publikationen genannte Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: NR1H2 fusion protein Ag5635
• Vollständiger Name: nuclear receptor subfamily 1, group H, member 2
• Berechnetes Molekulargewicht: 51 kDa
• Beobachtetes Molekulargewicht: 50 kDa, 40 kDa
• GenBank-Zugangsnummer: BC047750
• Gene symbol: NR1H2
• Gene ID (NCBI): 7376
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

NR1H2, also known as LXRB, is a liver X receptors, which form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. It preferentially bind to double-stranded oligonucleotide direct repeats, which have the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). It involves in the regulation of cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.

Publikationen

Species	Application	Title
mouse	WB	Nat Immunol; Atherogenic dyslipidemia promotes autoimmune follicular helper T cell responses via IL-27.; Authors - Heeju Ryu
mouse	WB	Br J Pharmacol; Targeting macrophage liver X receptors by hydrogel-encapsulated T0901317 reduces atherosclerosis without effect on hepatic lipogenesis.; Authors - Chuanrui Ma
mouse	WB	Int J Cancer; Inhibition of tumor growth by U0126 is associated with induction of interferon-γ production.; Authors - Xingzhe Ma ; KD Validated
mouse	WB	Sci Rep; Activation of liver X receptor inhibits the development of pulmonary carcinomas induced by 3-methylcholanthrene and butylated hydroxytoluene in BALB/c mice.; Authors - Qixue Wang
human	WB, IF	J Biol Chem; Regulation of hepatic cholesteryl ester transfer protein expression and reverse cholesterol transport by inhibition of DNA topoisomerase II.; Authors - Mengyang Liu
mouse	WB	Biochem J; Identification of interferon-γ as a new molecular target of liver X receptor.; Authors - Qixue Wang ; KD Validated