MCL1L-specific Polyklonaler Antikörper

MCL1L-specific Polyklonal Antikörper für IHC,ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

IHC,ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 15825-1-AP

Synonyme

EAT, Mcl 1, Mcl 1l, Mcl 1s Delta TM, MCL1, mcl1/EAT, MCL1L, MCL1S, TM

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Galerie der Validierungsdaten

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  IHC staining of human spleen using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 15825-1-AP (MCL1L-specific antibody at dilution of 1:50 (under 10x lens).

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  IHC staining of human spleen using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 15825-1-AP (MCL1L-specific antibody at dilution of 1:50 (under 40x lens).

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  IHC staining of human ovary using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human ovary using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 40x lens).

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  IHC staining of human kidney using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human kidney using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 10x lens).

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  IHC staining of human kidney using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human kidney using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 40x lens).

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  IHC staining of human placenta using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human placenta using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 10x lens).

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  IHC staining of human placenta using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human placenta using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 40x lens).

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  IHC staining of human testis using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human testis using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 10x lens).

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  IHC staining of human testis using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human testis using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 40x lens).

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  IHC staining of human skin using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human skin using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 10x lens).

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  IHC staining of human skin using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human skin using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 40x lens).

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  IHC staining of human brain using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human brain using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 10x lens).

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  IHC staining of human brain using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human brain using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 40x lens).

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  IHC staining of human spleen using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human spleen using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 10x lens).

• 

  IHC staining of human spleen using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human spleen using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 40x lens).

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  IHC staining of human lung using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human lung using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 10x lens).

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  IHC staining of human lung using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human lung using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 40x lens).

• 

  IHC staining of human ovary using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human ovary using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 10x lens).

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  IHC staining of human breast cancer using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 15825-1-AP (MCL1L-specific antibody at dilution of 1:50 (under 10x lens).

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  IHC staining of human breast cancer using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 15825-1-AP (MCL1L-specific antibody at dilution of 1:50 (under 40x lens).

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  IHC staining of human cervical cancer using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue slide using 15825-1-AP (MCL1L-specific antibody at dilution of 1:50 (under 10x lens).

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  IHC staining of human cervical cancer using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue slide using 15825-1-AP (MCL1L-specific antibody at dilution of 1:50 (under 40x lens).

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  IHC staining of human tonsillitis using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 15825-1-AP (MCL1L-specific antibody at dilution of 1:50 (under 10x lens).

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  IHC staining of human tonsillitis using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 15825-1-AP (MCL1L-specific antibody at dilution of 1:50 (under 40x lens).

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Geprüfte Anwendungen

• Erfolgreiche Detektion in IHC: humanes Milzgewebe, humanes Eierstockgewebe, humanes Hautgewebe, humanes Hirngewebe, humanes Hodengewebe, humanes Lungengewebe, humanes Mammakarzinomgewebe, humanes Nierengewebe, humanes Plazenta-Gewebe, humanes Tonsillitisgewebe, humanes Zervixkarzinomgewebe; Hinweis: Antigendemaskierung mit TE-Puffer pH 9,0 empfohlen. (*) Wahlweise kann die Antigendemaskierung auch mit Citratpuffer pH 6,0 erfolgen.

Empfohlene Verdünnung

• Immunhistochemie (IHC): IHC : 1:20-1:200

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Produktinformation

15825-1-AP bindet in IHC,ELISA MCL1L-specific und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: Peptid
• Vollständiger Name: myeloid cell leukemia sequence 1 (BCL2-related)
• Berechnetes Molekulargewicht: 37 kDa
• GenBank-Zugangsnummer: NM_182763
• Gene symbol: MCL1
• Gene ID (NCBI): 4170
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

MCL-1 is an anti-apoptotic member of the Bcl-2 family originally isolated from the ML-1 human myeloid leukemia cell line. Similar to BCL2 and BCL2L1, MCL1 can interact with BAX and/or BAK1 to inhibit mitochondria-mediated apoptosis. Mcl-1 is critical for the proliferation and survival of myeloma cells in vitro, and overexpression of Mcl-1 protein in myeloma cells is associated with relapse and short event-free survival in multiple myeloma patients. Recent studies show that MCL-1 is upregulated in numerous haematological and solid tumour malignancies. Therefore, MCL-1 has been suggested as a potential new therapeutic target. This antibody is specific to MCL1L isoform.