IL-36 Gamma Polyklonaler Antikörper

IL-36 Gamma Polyklonal Antikörper für IHC, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IHC, ELISA

Konjugation

Unkonjugiert

Publikationen

2

Kat-Nr. : 24723-1-AP

Synonyme

IL 1 epsilon, IL 1 related protein 2, IL 1F9, IL 1H1, IL 1RP2, IL1E, IL1F9, IL-1F9, IL1H1, IL1RP2, IL-36 gamma, IL-36γ, Interleukin 1 epsilon, Interleukin 1 family member 9, interleukin 1 family, member 9, Interleukin 1 homolog 1

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Galerie der Validierungsdaten

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  IHC staining of human colon cancer using 24723-1-AP

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 24723-1-AP (IL36 gamma antibody at dilution of 1:200 (under 10x lens).

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  IHC staining of human colon cancer using 24723-1-AP

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 24723-1-AP (IL36 gamma antibody at dilution of 1:200 (under 40x lens).

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  IHC staining of human ovary tumor using 24723-1-AP

  Immunohistochemical analysis of paraffin-embedded human ovary tumor tissue slide using 24723-1-AP (IL36 gamma antibody at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human ovary tumor using 24723-1-AP

  Immunohistochemical analysis of paraffin-embedded human ovary tumor tissue slide using 24723-1-AP (IL36 gamma antibody at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human pancreas using 24723-1-AP

  Immunohistochemical analysis of paraffin-embedded human pancreas tissue slide using 24723-1-AP (IL36 gamma antibody at dilution of 1:200 (under 10x lens).

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  IHC staining of human pancreas using 24723-1-AP

  Immunohistochemical analysis of paraffin-embedded human pancreas tissue slide using 24723-1-AP (IL36 gamma antibody at dilution of 1:200 (under 40x lens).

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Geprüfte Anwendungen

• Erfolgreiche Detektion in IHC: humanes Kolonkarzinomgewebe, humanes Ovarialkarzinomgewebe, humanes Pankreasgewebe; Hinweis: Antigendemaskierung mit TE-Puffer pH 9,0 empfohlen. (*) Wahlweise kann die Antigendemaskierung auch mit Citratpuffer pH 6,0 erfolgen.

Empfohlene Verdünnung

• Immunhistochemie (IHC): IHC : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 1 publications below
• WB: See 1 publications below
• IHC: See 1 publications below

Produktinformation

24723-1-AP bindet in WB, IHC, ELISA IL-36 Gamma und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• In Publikationen genannte Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: IL-36 Gamma fusion protein Ag21489
• Vollständiger Name: interleukin 1 family, member 9
• Berechnetes Molekulargewicht: 169 aa, 19 kDa
• GenBank-Zugangsnummer: BC098337
• Gene symbol: IL1F9
• Gene ID (NCBI): 56300
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

IL-36 Gamma is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection.

Publikationen

Species	Application	Title
human	IHC	J Cutan Pathol; IL-36α and IL-36γ expressions in the differential diagnosis of palmoplantar psoriasis and palmoplantar eczema: A retrospective histopathologic and immunohistochemical study.; Authors - Ozan Erdem
human	WB	Sci Immunol; Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement; Authors - Graeme P Sullivan ; KD Validated