NeutraKine® IL-17A Monoklonaler Antikörper
NeutraKine® IL-17A Monoklonal Antikörper für Neutralization, ELISA
Wirt / Isotyp
Maus / IgG1
Getestete Reaktivität
human
Anwendung
Neutralization, Cell treatment, ELISA
Konjugation
Unkonjugiert
CloneNo.
1F3E3
Kat-Nr. : 69021-1-Ig
Synonyme
Galerie der Validierungsdaten
| Neutralization | HT-1080 cell |
Produktinformation
69021-1-Ig bindet in Neutralization, Cell treatment, ELISA NeutraKine® IL-17A und zeigt Reaktivität mit human
| Getestete Reaktivität | human |
| In Publikationen genannte Reaktivität | human |
| Wirt / Isotyp | Maus / IgG1 |
| Klonalität | Monoklonal |
| Typ | Antikörper |
| Immunogen | human Humankine IL-17A protein HZ-1113 |
| Vollständiger Name | interleukin 17A |
| Gene symbol | IL17A |
| Gene ID (NCBI) | 3605 |
| Konjugation | Unkonjugiert |
| Form | Lyophilized Powder |
| Reinigungsmethode | Protein-A-Reinigung |
| Lagerungspuffer | Sterile PBS. |
| Endotoxin | <0.1 EU/μg |
| Wiederherstellung | This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use. |
| Stability and Storage | Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products. |
Hintergrundinformationen
IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased.
This antibody can be used to neutralize the bioactivity of IL-17A.
Publikationen
| Species | Application | Title |
|---|---|---|
Int J Chron Obstruct Pulmon Dis IL-17A Promotes Epithelial ADAM9 Expression in Cigarette Smoke-Related COPD | ||
JCI Insight Targeting mTOR with a sirolimus-eluting airway stent reduces pro-fibrotic TH17-cells and inhibits laryngotracheal stenosis |
