IKBKB Monoklonaler Antikörper
IKBKB Monoklonal Antikörper für IHC,ELISA
Wirt / Isotyp
Maus / IgG1
Getestete Reaktivität
human, Maus
Anwendung
IHC,ELISA
Konjugation
Unkonjugiert
Kat-Nr. : 65036-1-Ig
Synonyme
Galerie der Validierungsdaten
Geprüfte Anwendungen
| Erfolgreiche Detektion in IHC | bladder carcinoma tissue Hinweis: Antigendemaskierung mit TE-Puffer pH 9,0 empfohlen. (*) Wahlweise kann die Antigendemaskierung auch mit Citratpuffer pH 6,0 erfolgen. |
Empfohlene Verdünnung
| Anwendung | Verdünnung |
|---|---|
| Immunhistochemie (IHC) | IHC : 1:20-1:200 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, check data in validation data gallery | |
Produktinformation
65036-1-Ig bindet in IHC,ELISA IKBKB und zeigt Reaktivität mit human, Maus
| Getestete Reaktivität | human, Maus |
| Wirt / Isotyp | Maus / IgG1 |
| Klonalität | Monoklonal |
| Typ | Antikörper |
| Immunogen | Rekombinantes Protein |
| Vollständiger Name | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta |
| Berechnetes Molekulargewicht | 756aa,81 kDa; 256aa,29 kDa |
| Beobachtetes Molekulargewicht | 87 kDa |
| GenBank-Zugangsnummer | BC006231 |
| Gene symbol | IKBKB |
| Gene ID (NCBI) | 3551 |
| Konjugation | Unkonjugiert |
| Form | Liquid |
| Reinigungsmethode | Antigen-Affinitätsreinigung |
| Lagerungspuffer | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. |
| Lagerungsbedingungen | Bei 2-8℃ lagern. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
KBKB, also named as IKKB, IKK2, NFKBIKB and IKK-B, belongs to the protein kinase superfamily, Ser/Thr protein kinase family and I-kappa-B kinase subfamily. IKBKB is a Serine kinase that plays an essential role in the NF-kappa-B signaling pathway. It acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. In addition to the NF-kappa-B inhibitors, IKBKB phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. It also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, IKBKB acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
