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EMILIN1 Monoklonaler Antikörper

EMILIN1 Monoklonal Antikörper für IF

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human

Anwendung

IF

Konjugation

CoraLite®594 Fluorescent Dye

CloneNo.

2A5C8

Kat-Nr. : CL594-60047

Synonyme

DKFZp586M121, EMI, EMILIN, EMILIN 1, EMILIN1, gp115

Galerie der Validierungsdaten

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  • Immunofluorescence (IF) / fluorescent staining of human ovary tumor tissue using CoraLite®594-conjugated EMILIN1 Monoclonal antibod (CL594-60047)

    IF Staining of human ovary tumor using CL594-60047

    Immunofluorescent analysis of (4% PFA) fixed human ovary tumor tissue using CoraLite®594 EMILIN1 antibody (CL594-60047, Clone: 2A5C8 ) at dilution of 1:200.

  • Immunofluorescence (IF) / fluorescent staining of human ovary tumor tissue using CoraLite®594-conjugated EMILIN1 Monoclonal antibod (CL594-60047)

    IF Staining of human ovary tumor using CL594-60047

    Immunofluorescent analysis of (4% PFA) fixed human ovary tumor tissue using CoraLite®594 EMILIN1 antibody (CL594-60047, Clone: 2A5C8 ) at dilution of 1:200.

Geprüfte Anwendungen

Erfolgreiche Detektion in IFhumanes Ovarialkarzinomgewebe

Empfohlene Verdünnung

AnwendungVerdünnung
Immunfluoreszenz (IF)IF : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

CL594-60047 bindet in IF EMILIN1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Maus / IgG1
Klonalität Monoklonal
Typ Antikörper
Immunogen EMILIN1 fusion protein Ag1016
Vollständiger Name elastin microfibril interfacer 1
Berechnetes Molekulargewicht 107 kDa
Beobachtetes Molekulargewicht 120-130 kDa
GenBank-ZugangsnummerBC007530
Gene symbol EMILIN1
Gene ID (NCBI) 11117
Konjugation CoraLite®594 Fluorescent Dye
Excitation/Emission maxima wavelengths588 nm / 604 nm
Form Liquid
Reinigungsmethode Protein-G-Reinigung
Lagerungspuffer BS mit 50% Glyzerin, 0,05% Proclin300, 0,5% BSA, pH 7,3.
LagerungsbedingungenBei -20°C lagern. Vor Licht schützen. Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

EMILIN1, also named as EMILIN, EMILIN-1, gp115 and EMI, may be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. It has cell adhesive capacity. EMILIN1 is a negative regulator of the transforming growth factor-beta (TGF-beta) signaling, which is involved in blood pressure (BP) homeostasis (PMID:20186130). EMILIN1 may play a key role in hypertensive vascular remodeling. TGFβ proteins are the main regulators of blood vessel development and maintenance, and EMILIN1 inhibits TGFβ signaling by binding specifically to the proTGFβ precursor and preventing its maturation by furin convertases in the extracellular space (PMID:19922630).

Protokolle

Produktspezifische Protokolle
IF protocol for CL594 EMILIN1 antibody CL594-60047Protokoll herunterladen
Standard-Protokolle
Klicken Sie hier, um unsere Standardprotokolle anzuzeigen