CXCL16 Monoklonaler Antikörper

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• KD/KO Validated

CXCL16 Monoklonal Antikörper für WB,ELISA

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human, Maus und mehr (1)

Anwendung

WB, IHC, IF, ELISA

Konjugation

Unkonjugiert

Publikationen

4

CloneNo.

2H7B3

Kat-Nr. : 60123-1-Ig

Synonyme

C X C motif chemokine 16, CXCL16, CXCLG16, SCYB16, Small inducible cytokine B16, SR PSOX, SRPSOX, Transmembrane chemokine CXCL16

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Galerie der Validierungsdaten

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  WB analysis of SH-SY5Y using 60123-1-Ig

  SH-SY5Y cells were subjected to SDS PAGE followed by western blot with 60123-1-Ig (CXCL16 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: SH-SY5Y-Zellen

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:200-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 1 publications below
• WB: See 2 publications below
• IHC: See 1 publications below
• IF: See 1 publications below

Produktinformation

60123-1-Ig bindet in WB, IHC, IF, ELISA CXCL16 und zeigt Reaktivität mit human, Maus

• Getestete Reaktivität: human, Maus
• In Publikationen genannte Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Maus / IgG2a
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: CXCL16 fusion protein Ag4883
• Vollständiger Name: chemokine (C-X-C motif) ligand 16
• Berechnetes Molekulargewicht: 273 aa, 30 kDa
• Beobachtetes Molekulargewicht: 35 kDa, 60 kDa
• GenBank-Zugangsnummer: BC017588
• Gene symbol: CXCL16
• Gene ID (NCBI): 58191
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Caprylsäure/Ammoniumsulfat-Präzipitation
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CXCL16 is a recently discovered cytokine belonging to the CXC chemokine family, which is synthesised in plasmacytoid dendritic cell as a transmembrane molecule. It exists in a transmembrane and soluble form. The transmembrane form of CXCL16 functions as an adhesion molecule for CXCR6-expressing cells, whereas the soluble form of CXCL16 mediates infiltration of circulating cells into sites of injury. CXCL16, has been proposed as an important pathogenic mediator in inflammatory diseases, including rheumatoid arthritis, glomerulonephritis, or prostate cancer. CXCL16 has been implicated in some forms of renal disease such as lupus nephritis and antiglomerular basement membrane nephritis. CXCL16 also plays a pivotal role in the pathogenesis of angiotensin II-induced renal injury and fibrosis through regulation of macrophage and T cell infiltration and bone marrow-derived fibroblast accumulation.

Publikationen

Species	Application	Title
rat	IHC	Cancer Commun (Lond); Activation of Piezo1 contributes to matrix stiffness-induced angiogenesis in hepatocellular carcinoma; Authors - Miao Li
mouse	WB	FASEB J; Pathogenic Tconvs promote inflammatory macrophage polarization through GM-CSF and exacerbate abdominal aortic aneurysm formation.; Authors - Dan Li
mouse	WB	Mol Med Rep; oxLDL promotes podocyte migration by regulating CXCL16, ADAM10 and ACTN4.; Authors - Yuan Chen ; KO Validated
human,mouse	IF	Cardiovasc Diabetol; Klotho inhibits renal ox-LDL deposition via IGF-1R/RAC1/OLR1 signaling to ameliorate podocyte injury in diabetic kidney disease; Authors - Wei Jiang