CPT1C Monoklonaler Antikörper

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• KD/KO Validated

CPT1C Monoklonal Antikörper für IHC, WB, ELISA

Wirt / Isotyp

Maus / IgG2b

Getestete Reaktivität

Hausschwein, human und mehr (2)

Anwendung

WB, IHC, IF, ELISA

Konjugation

Unkonjugiert

Publikationen

7

CloneNo.

5D11B5

Kat-Nr. : 66072-1-Ig

Synonyme

CATL1, CPT IC, CPT1 B, CPT1C, CPT1P, CPTI B, CPTIC

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Galerie der Validierungsdaten

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  WB analysis of human brain using 66072-1-Ig

  human brain tissue were subjected to SDS PAGE followed by western blot with 66072-1-Ig (CPT1C antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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  IHC staining of human testis using 66072-1-Ig

  Immunohistochemical analysis of paraffin-embedded human testis using 66072-1-Ig(CPT1C antibody) at dilution of 1:50 (under 10x lens).

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  IHC staining of human testis using 66072-1-Ig

  Immunohistochemical analysis of paraffin-embedded human testis using 66072-1-Ig(CPT1C antibody) at dilution of 1:50 (under 40x lens).

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: Human brain, humanes Hirngewebe
• Erfolgreiche Detektion in IHC: humanes Hodengewebe; Hinweis: Antigendemaskierung mit TE-Puffer pH 9,0 empfohlen. (*) Wahlweise kann die Antigendemaskierung auch mit Citratpuffer pH 6,0 erfolgen.

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:500-1:1000
• Immunhistochemie (IHC): IHC : 1:20-1:200

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 3 publications below
• WB: See 7 publications below
• IF: See 1 publications below

Produktinformation

66072-1-Ig bindet in WB, IHC, IF, ELISA CPT1C und zeigt Reaktivität mit Hausschwein, human

• Getestete Reaktivität: Hausschwein, human
• In Publikationen genannte Reaktivität: human, Hausschwein, Maus, Ratte
• Wirt / Isotyp: Maus / IgG2b
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: CPT1C fusion protein Ag17963
• Vollständiger Name: carnitine palmitoyltransferase 1C
• Berechnetes Molekulargewicht: 792 aa, 90 kDa
• Beobachtetes Molekulargewicht: 82 kDa
• GenBank-Zugangsnummer: BC029104
• Gene symbol: CPT1C
• Gene ID (NCBI): 126129
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CPT1C, also named as CATL1, CPTI-B and B-CPTI, belongs to the carnitine/choline acetyltransferase family. Carnitine palmitoyltransferase (CPT) deficiencies are common disorders of mitochondrial fatty acid oxidation. The CPT system is made up of two separate proteins located in the outer (CPT1) and inner (CPT2) mitochondrial membranes. CPT1C is an active forms of related brain-type carnitine palmitoyltransferase I. CPT1C may be a regulated target of malonyl-CoA that relays the "malonyl-CoA signal" in hypothalamic neurons that express the orexigenic and anorexigenic neuropeptides that regulate food intake and peripheral energy expenditure. (PMID: 17018521 ) This antibody can bind the close sequences genes.

Publikationen

Species	Application	Title
human	WB	Hepatology; Discovery of a CPS1-deficient HCC subtype with therapeutic potential via integrative genomic and experimental analysis.; Authors - Tong Wu ; KD Validated
human,mouse	WB,IF	Cancer Metab; MicroRNA-377-3p inhibits hepatocellular carcinoma growth and metastasis through negative regulation of CPT1C-mediated fatty acid oxidation.; Authors - Ting Zhang
pig	WB	Epigenetics; Differential regulatory roles of microRNAs during intramuscular adipogenesis in Chinese Guizhou Congjiang Xiang pigs.; Authors - Lulin Tan
rat	WB	J Biochem Mol Toxicol; Polyphyllin I improves myocardial damage in coronary artery disease via modulating lipid metabolism and myocardial apoptosis; Authors - Zhao Yang
human	WB	J Gastrointest Oncol; Enhanced fatty acid oxidation mediated by CPT1C promotes gastric cancer progression.; Authors - Tianyi Chen ; KD Validated
human	WB	Int J Mol Sci; Cpt1c Downregulation Causes Plasma Membrane Remodelling and Anthracycline Resistance in Breast Cancer; Authors - Helena Muley ; KD Validated