CDK5RAP2-Specific Polyklonaler Antikörper
CDK5RAP2-Specific Polyklonal Antikörper für ELISA
Wirt / Isotyp
Kaninchen / IgG
Getestete Reaktivität
human
Anwendung
WB, IF, ELISA
Konjugation
Unkonjugiert
Kat-Nr. : 20061-1-AP
Synonyme
Galerie der Validierungsdaten
Geprüfte Anwendungen
Empfohlene Verdünnung
| Anwendung | Verdünnung |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, check data in validation data gallery | |
Veröffentlichte Anwendungen
| WB | See 1 publications below |
| IF | See 1 publications below |
Produktinformation
20061-1-AP bindet in WB, IF, ELISA CDK5RAP2-Specific und zeigt Reaktivität mit human
| Getestete Reaktivität | human |
| In Publikationen genannte Reaktivität | human |
| Wirt / Isotyp | Kaninchen / IgG |
| Klonalität | Polyklonal |
| Typ | Antikörper |
| Immunogen | Peptid |
| Vollständiger Name | CDK5 regulatory subunit associated protein 2 |
| Berechnetes Molekulargewicht | 215 kDa |
| GenBank-Zugangsnummer | NM_001011649 |
| Gene symbol | CDK5RAP2 |
| Gene ID (NCBI) | 55755 |
| Konjugation | Unkonjugiert |
| Form | Liquid |
| Reinigungsmethode | Antigen-Affinitätsreinigung |
| Lagerungspuffer | PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3. |
| Lagerungsbedingungen | Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
CDK5RAP2, also named as CEP215 and KIAA1633, belongs to the methylthiotransferase family and MiaB subfamily. This protein binds to p25NCK5A and therefore may be involved in neuronal differentiation. It may also be a substrate of neuronal CDC2-like kinase. CDK5RAP2 specifically inhibits CDK5 activation by CDK5R1. Defects in CDK5RAP2 are the cause of primary microcephaly autosomal recessive type 3 (MCPH3). Multiple isoforms generated through co- and/or posttranslational modifications or degradation may exist as scientists have described bands of 70, 90, 105, 200, and 230 kDa in mice depending on the age and organ investigated as well as the anti-Cdk5rap2 antibody applied or 210kd in total cell lysates of some human canser cell lines. (PUMID: 21327915, 20471352 and 18042621). The antibody is specific to CDK5RAP2.
Publikationen
| Species | Application | Title |
|---|---|---|
PLoS Biol The ciliopathy protein CCDC66 controls mitotic progression and cytokinesis by promoting microtubule nucleation and organization. |
