CD49b Monoklonaler Antikörper

CD49b Monoklonal Antikörper für FC

Wirt / Isotyp

Ratte / IgM, kappa

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

Publikationen

1

CloneNo.

DX5

Kat-Nr. : 65065-1-Ig

Synonyme

CD49B, DX5, integrin alpha 2, Itga2

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Galerie der Validierungsdaten

• 

  FC experiment of mouse splenocytes using 65065-1-Ig

  1X10^6 mouse splenocytes were surface stained with 0.5 ug Anti-Mouse CD49b (65065-1-Ig, Clone: DX5) and FITC anti-rat IgM Antibody at dilution 1:50 (green), or stained with 0.5 ug rat IgM isotype control and FITC anti-rat IgM Antibody at dilution 1:50 (black). Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: Maus-Splenozyten

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• FC: See 1 publications below

Produktinformation

65065-1-Ig bindet in FC CD49b und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• In Publikationen genannte Reaktivität: Maus
• Wirt / Isotyp: Ratte / IgM, kappa
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: Aus C57BL/6-Mäusen isolierte NK-Zellen
• Vollständiger Name: integrin alpha 2
• GenBank-Zugangsnummer: BC065139
• Gene symbol: Itga2
• Gene ID (NCBI): 16398
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Affinitätsreinigung
• Lagerungspuffer: Borat-gepufferte Kochsalzlösung, pH 8,2.
• Lagerungsbedingungen: Store at 2-8°C. Stable for one year after shipment.

Hintergrundinformationen

Integrins are a large family of α/β transmembrane receptors playing a key role in cell-cell interactions and cell adhesion to the extracellular matrix (PMID: 30374344). CD49b, also known as integrin alpha-2, is a 150 kDa transmembrane glycoprotein expressed on a wide variety of cell types including platelets, megakaryocytes, NK cells, NKT cells, neutrophils, and long-term activated T cells (PMID: 18802064; 2415516). Integrin alpha-2/beta-1 (also known as VLA-2) is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin (PMID: 2557634). It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.

Publikationen

Species	Application	Title
mouse	FC	Nanoscale Adv; Bacteria-mediated tumor immunotherapy via photothermally-programmed PD1 expression; Authors - Wenxuan Xu