CD41a Monoklonaler Antikörper

CD41a Monoklonal Antikörper für FC

Wirt / Isotyp

Maus / Mouse IgG1

Getestete Reaktivität

human, nicht-humane Primaten

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

HIP8

Kat-Nr. : 65173-1-Ig

Synonyme

CD41, CD41a, CD41B, GP2B, GPalpha IIb, GPIIb, GTA, HIP8, HPA3, Integrin alpha IIb, ITGA2B, ITGAB

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Galerie der Validierungsdaten

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  FC experiment of human peripheral blood platelets using 65173-1-Ig

  1X10^6 human peripheral blood platelets were surface stained with 0.40 ug Purified Anti-Human CD41a (65173-1-Ig, Clone:HIP8) (red) or 0.40 ug Mouse IgG1 Isotype Control (blue) and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L) with dilution 1:1000. Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: Human peripheral blood platelets

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

65173-1-Ig bindet in FC CD41a und zeigt Reaktivität mit human, nicht-humane Primaten

• Getestete Reaktivität: human, nicht-humane Primaten
• Wirt / Isotyp: Maus / Mouse IgG1
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: k.A.
• Vollständiger Name: integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
• GenBank-Zugangsnummer: BC117443
• Gene symbol: ITGA2B
• Gene ID (NCBI): 3674
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Mit Protein-A-Affinitätschromatographie gereinigt
• Lagerungspuffer: PBS mit 0,1% Natriumazid.
• Lagerungsbedingungen: Bei 2-8℃ lagern.

Hintergrundinformationen

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID:19118207). Integrin alpha-IIb (ITGA2B, CD41) is expressed on platelets, megakaryocytes and some hematopoietic progenitor cells (PMID: 11934866).