CD134 Monoklonaler Antikörper

CD134 Monoklonal Antikörper für FC

Wirt / Isotyp

Ratte / IgG1, kappa

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

APC Fluorescent Dye

CloneNo.

OX-86

Kat-Nr. : APC-65136

Synonyme

ACT35, CD134, Ly 70, Ox40, Tnfrsf4, Txgp1, TXGP1L

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Galerie der Validierungsdaten

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  FC experiment of BALB/C mouse splenocytes using APC-65136

  1X10^6 unstimulated or anti-CD3/CD28 stimulated (2 days) mouse splenocytes were surface co-stained with FITC Plus Anti-Mouse CD3 (17A2) (FITC-65077, Clone: 17A2) and 0.2 ug APC Anti-Mouse CD134 (APC-65136, Clone: OX-86). Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: Anti-CD3/CD28 treated mouse splenocytes

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

APC-65136 bindet in FC CD134 und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Ratte / IgG1, kappa
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: Rekombinantes Maus-OX-40-CD4-chimäres Protein
• Vollständiger Name: tumor necrosis factor receptor superfamily, member 4
• GenBank-Zugangsnummer: BC065782
• Gene symbol: Tnfrsf4
• Gene ID (NCBI): 22163
• Konjugation: APC Fluorescent Dye
• Excitation/Emission maxima wavelengths: 650 nm / 660 nm
• Form: Liquid
• Reinigungsmethode: Affinitätsreinigung
• Lagerungspuffer: PBS with 0.1% sodium azide and 0.5% BSA.
• Lagerungsbedingungen: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Hintergrundinformationen

CD134, also known as OX40 and TNFRSF4, is a member of the TNFR-superfamily of receptors (PMID: 2828930; 9766631). It is a type I transmembrane protein predominantly expressed on activated T cells which include CD4 and CD8 T cells, Th2, Th1, and Th17 cells, as well as regulatory T cells (Tregs) (PMID: 20307208). CD134 is activated by its cognate ligand CD134L (OX40L) and functions as a T cell co-stimulatory molecule (PMID: 26215166). CD134-CD134L interactions have been proposed as a potential therapeutic target for treating autoimmune diseases, cancer and infectious disease (PMID: 26215166; 19426222).