CD11c Monoklonaler Antikörper

CD11c Monoklonal Antikörper für FC

Wirt / Isotyp

Armenian Hamster / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

N418

Kat-Nr. : 65130-1-Ig

Synonyme

AI449405, Cd11c, Cr4, integrin alpha X, Itgax, N418

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Galerie der Validierungsdaten

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  FC experiment of C57BL/6 mouse splenocytes using 65130-1-Ig

  1X10^6 C57BL/6 mouse splenocytes were surface co-stained with APC Anti-Mouse MHC Class II (I-A/I-E) (M5/114.15.2) and 0.5 ug Anti-Mouse CD11c (65130-1-Ig, Clone:N418) and FITC anti-Armenian Hamster IgG Antibody at dilution 1:100, or 0.5 ug Armenian Hamster IgG Isotype Control (PIP) and FITC anti-Armenian Hamster IgG Antibody at dilution 1:100. Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: C57BL/6 mouse splenocytes

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

65130-1-Ig bindet in FC CD11c und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Armenian Hamster / IgG
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: Dendritische Mausmilzzellen
• Vollständiger Name: integrin alpha X
• GenBank-Zugangsnummer: BC167225
• Gene symbol: Itgax
• Gene ID (NCBI): 16411
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.09% sodium azide.
• Lagerungsbedingungen: Store at 2-8°C. Stable for one year after shipment.

Hintergrundinformationen

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11c, also known as integrin αX, is a type I transmembrane glycoprotein present on a variety of cells, including monocytes/macrophages, granulocytes, a subset of B cells, NK cells and dendritic cells (PMID: 2897326; 1680915; 1694698; 17389580). As a result of its high level of expression on most dendritic cells, CD11c is typically considered to be a marker of conventional dendritic cells (PMID: 27119555). CD11c forms an α/β heterodimer with CD18 (integrin β2). CD11c/CD18 acts a receptor for fibrinogen and is important in monocyte adhesion and chemotaxis (PMID: 1671533).