ASGR1 Polyklonaler Antikörper

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• KD/KO Validated

ASGR1 Polyklonal Antikörper für IF

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

IF

Konjugation

CoraLite®594 Fluorescent Dye

Kat-Nr. : CL594-11739

Synonyme

ASGP R 1, ASGPR, ASGPR 1, ASGR1, asialoglycoprotein receptor 1, CLEC4H1, Hepatic lectin H1, HL 1, Hs.12056

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Galerie der Validierungsdaten

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  IF Staining of rat liver using CL594-11739

  Immunofluorescent analysis of (4% PFA) fixed rat liver tissue using CoraLite®594 ASGR1 antibody (CL594-11739) at dilution of 1:200.

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  IF Staining of rat liver using CL594-11739

  Immunofluorescent analysis of (4% PFA) fixed rat liver tissue using CoraLite®594 ASGR1 antibody (CL594-11739) at dilution of 1:200.

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  IF Staining of human liver cancer using CL594-11739

  Immunofluorescent analysis of (4% PFA) fixed human liver cancer tissue using CoraLite®594 ASGR1 antibody (CL594-11739) at dilution of 1:200.

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  IF Staining of human liver cancer using CL594-11739

  Immunofluorescent analysis of (4% PFA) fixed human liver cancer tissue using CoraLite®594 ASGR1 antibody (CL594-11739) at dilution of 1:200.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in IF: Rattenlebergewebe, humanes Leberkarzinomgewebe

Empfohlene Verdünnung

• Immunfluoreszenz (IF): IF : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Produktinformation

CL594-11739 bindet in IF ASGR1 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: ASGR1 fusion protein Ag2310
• Vollständiger Name: asialoglycoprotein receptor 1
• Berechnetes Molekulargewicht: 291 aa, 33 kDa
• GenBank-Zugangsnummer: BC032130
• Gene symbol: ASGR1
• Gene ID (NCBI): 432
• Konjugation: CoraLite®594 Fluorescent Dye
• Excitation/Emission maxima wavelengths: 588 nm / 604 nm
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: BS mit 50% Glyzerin, 0,05% Proclin300, 0,5% BSA, pH 7,3.
• Lagerungsbedingungen: Bei -20°C lagern. Vor Licht schützen. Nach dem Versand ein Jahr stabil. Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Asialoglycoprotein receptor (ASGPR), also known as the hepatic galactose/N-acetylglucosamine (GlcNAc) receptor or Ashwell receptor, is a C-type lectin expressed exclusively in hepatic parenchymal cells. ASGPR consists of two subunits, a major subunit (ASGR1, HL-1) and a minor subunit (ASGR2, HL-2), and specifically recognizes terminal β-linked galactose or GlcNAc on circulating glycoproteins or cells. This receptor plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins that contain terminal galactose or GlcNAc residues. ASGPR may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery.